Tavares Sánchez-Monge F J, Aguado Maestro I, Bañuelos Díaz A, Martín Ferrero M Á, García Alonso M F
Servicio Jerarquizado de Traumatología, Hospital Universitario del Río Hortega, Valladolid, España.
Servicio Jerarquizado de Traumatología, Hospital Universitario del Río Hortega, Valladolid, España.
Rev Esp Cir Ortop Traumatol (Engl Ed). 2018 Jan-Feb;62(1):47-54. doi: 10.1016/j.recot.2017.09.003. Epub 2017 Nov 8.
To evaluate the efficacy of topical tranexamic acid topical in cementless total hip arthroplasty from the point of view of bleeding, transfusion requirements and length of stay, and describe the complications of use compared to a control group.
A prospective, randomised, double-blinded and controlled study including all patients undergoing cementless total hip arthroplasty in our centre between June 2014 and July 2015. Blood loss was estimated using the formula described by Nadler and Good.
The final analysis included 119 patients. The decrease in haemoglobin after surgery was lower in the tranexamic acid group (3.28±1.13g/dL) than in the controls (4.03±1.27g/dL, P=.001) and estimated blood loss (1,216.75±410.46mL vs. 1,542.12±498.97mL, P<.001), the percentage of transfused patients (35.9% vs. 19.3%, P<.05) and the number of transfused red blood cell units per patient (0.37±0.77 vs. 0.98±1.77; P<.05). There were no differences between groups in the occurrence of complications or length of stay.
The use of topical tranexamic acid in cementless total hip arthroplasty results in a decrease in bleeding and transfusion requirements without increasing the incidence of complications.
从出血、输血需求和住院时间的角度评估氨甲环酸局部应用于非骨水泥型全髋关节置换术的疗效，并描述与对照组相比使用氨甲环酸的并发症情况。
一项前瞻性、随机、双盲和对照研究，纳入了2014年6月至2015年7月在本中心接受非骨水泥型全髋关节置换术的所有患者。采用Nadler和Good描述的公式估算失血量。
最终分析纳入了119例患者。氨甲环酸组术后血红蛋白下降幅度（3.28±1.13g/dL）低于对照组（4.03±1.27g/dL，P = 0.001），估计失血量也低于对照组（1216.75±410.46mL对1542.12±498.97mL，P<0.001），输血患者百分比（35.9%对19.3%，P<0.05）以及每位患者输注红细胞单位数（0.37±0.77对0.98±1.77；P<0.05）。两组在并发症发生率或住院时间方面无差异。
在非骨水泥型全髋关节置换术中局部应用氨甲环酸可减少出血和输血需求，且不增加并发症发生率。
