Osborne B M
Department of Pathology, University of Texas, M. D. Anderson Cancer Center, Houston 77030.
Hum Pathol. 1989 Jan;20(1):47-52. doi: 10.1016/0046-8177(89)90201-3.
Two cases of a lobular, necrotizing granulomatous process causing a unilateral painful breast mass mimicking carcinoma are presented for comparison. While the morphologic appearance in each case was that of lobular granulomatous mastitis, the etiologic agent in one case appeared to be Histoplasma capsulatum, based on Grocott methenamine silver staining, and represents the second reported case of histoplasmosis involving only breast parenchyma. Awareness of the rare entity, granulomatous mastitis, is important for the pathologist because the definitive diagnosis is made microscopically. Thorough evaluation of the breast tissue is essential for its management and should eventually contribute to the clarification of its etiology.
本文报告两例小叶性坏死性肉芽肿性病变，其导致单侧疼痛性乳腺肿块，酷似癌，以供比较。虽然每例的形态学表现均为小叶性肉芽肿性乳腺炎，但根据Grocott六胺银染色，其中一例的病原体似乎是荚膜组织胞浆菌，这是第二例仅累及乳腺实质的组织胞浆菌病报告。认识到罕见的肉芽肿性乳腺炎实体对病理学家很重要，因为最终诊断是通过显微镜作出的。对乳腺组织进行全面评估对其治疗至关重要，最终应有助于明确其病因。
