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嗜酸性食管炎的内镜治疗

Endoscopic Treatment of Eosinophilic Esophagitis.

作者信息

Richter Joel E

机构信息

Division of Digestive Diseases & Nutrition, Joy McCann Culverhouse Center for Swallowing Disorders, University of South Florida Morsani College of Medicine, 12901 Bruce B. Downs Boulevard, MDC 72, Tampa, FL 33612, USA.

出版信息

Gastrointest Endosc Clin N Am. 2018 Jan;28(1):97-110. doi: 10.1016/j.giec.2017.07.009.

Abstract

In eosinophilic esophagitis, the main cause of solid-food dysphagia is tissue remodeling resulting in strictures and narrowed esophagus. Endoscopy and biopsies help to identify the degree of inflammation but often miss the fibrosis. Although initially considered dangerous, esophageal dilation has evolved into an extremely effective and safe treatment in fibrostenotic disease. The key is starting low with small-diameter bougies or balloons, and gradually dilating the esophagus and strictures to 16 to 18 mm. Results in more than 1000 adults and children have shown low rates of complications, especially perforations, and no deaths, but postprocedure chest pain is common.

摘要

在嗜酸性食管炎中,固体食物吞咽困难的主要原因是组织重塑导致食管狭窄和食管变窄。内镜检查和活检有助于确定炎症程度,但常常遗漏纤维化情况。尽管食管扩张术最初被认为有风险,但在纤维狭窄性疾病中已发展成为一种极其有效且安全的治疗方法。关键是从小直径探条或球囊开始,以较低规格进行扩张,并逐渐将食管和狭窄部位扩张至16至18毫米。对1000多名成人和儿童的治疗结果显示,并发症发生率较低,尤其是穿孔发生率低,且无死亡病例,但术后胸痛很常见。

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