Russell K J, Hoppe R T
Department of Radiation Oncology, University of Washington, Seattle 98195.
Int J Radiat Oncol Biol Phys. 1989 Jan;16(1):201-4. doi: 10.1016/0360-3016(89)90030-8.
The record of 18 patients with Stage II Hodgkin's disease and large mediastinal masses, who received radiation therapy as sole treatment for their disease, were reviewed. The ratio of each patient's maximum tumor diameter to his maximum transthoracic diameter was measured from radiographs taken prior to treatment, and at two intervals approximating 1/3 and 2/3 the total radiation dose. The slopes of the resulting graphed data points were correlated with patient outcomes. No correlation could be drawn between prompt or slow tumor regression and freedom from tumor recurrence. It is concluded that the rate of tumor mass regression in Hodgkin's disease is not predictive of the ultimate success or failure of radiation therapy, and should not be used as a criterion by which to judge the need for additional systemic chemotherapy.
对18例II期霍奇金病并伴有大纵隔肿块且仅接受放射治疗的患者记录进行了回顾。从治疗前拍摄的X光片以及在总放射剂量的大约1/3和2/3两个时间点拍摄的X光片中，测量每位患者肿瘤最大直径与其最大胸廓横径的比值。将所得绘制成图的数据点的斜率与患者的预后相关联。肿瘤迅速或缓慢消退与无肿瘤复发之间未发现相关性。得出的结论是，霍奇金病中肿瘤肿块消退的速度不能预测放射治疗的最终成败，也不应作为判断是否需要额外全身化疗的标准。
