Department of Neurosciences and Mental Health, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, University of Milan, Milan, Italy.
IRCCS "E. Medea" Scientific Institute, San Vito al Tagliamento (PN), Italy.
Psychiatry Res Neuroimaging. 2018 Jan 30;271:75-81. doi: 10.1016/j.pscychresns.2017.11.001. Epub 2017 Nov 3.
Structural and diffusion imaging studies have provided some evidence of abnormal organization of Corpus Callosum (CC) in Bipolar Disorder (BD). Therefore, by using Diffusion Weighted Imaging (DWI), which allows to build subtle prediction models of fiber integrity for white matter (WM) tracts, this study aims to further explore the microstructure integrity of CC in BD patients compared to matched healthy controls. Twenty-four chronic patients with BD and 35 healthy controls were included in the study. Circular regions of interest were placed, on diffusion images, in the left and right side of callosal regions (i.e. rostrum/genu, anterior body, posterior body, splenium) and the Apparent Diffusion Coefficient (ADC) was then calculated. Significantly increased ADC values were found in right anterior body and in right splenium in BD patients compared to healthy controls (all p < 0.05, Bonferroni corrected). In this study, we found abnormally increased ADC callosal values in BD suggesting microstructural anomalies specifically in the right hemisphere. Interestingly, this finding further supports the presence of an altered inter-hemispheric communication between frontal and temporo-parietal association areas in patients with BD, which may ultimately result in clinical symptoms and cognitive deficits.
结构和扩散成像研究为双相情感障碍（BD）患者胼胝体（CC）的组织结构异常提供了一些证据。因此，本研究通过使用弥散加权成像（DWI），可以为白质（WM）束的纤维完整性建立微妙的预测模型，旨在进一步探索与匹配的健康对照组相比，BD 患者 CC 的微观结构完整性。本研究纳入了 24 名慢性 BD 患者和 35 名健康对照者。在弥散图像上，在 CC 的左侧和右侧（即喙部/膝部、前体部、后体部、压部）放置圆形感兴趣区，并计算表观弥散系数（ADC）。与健康对照组相比，BD 患者右侧前体部和右侧压部的 ADC 值显著升高（均 P < 0.05，经 Bonferroni 校正）。在这项研究中，我们发现 BD 患者的胼胝体 ADC 值异常升高，提示右侧半球存在微观结构异常。有趣的是，这一发现进一步支持了 BD 患者额颞联合区之间存在异常的大脑半球间通讯，这可能最终导致临床症状和认知缺陷。
