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自噬在肠道疾病中的机制和功能。

Mechanisms and function of autophagy in intestinal disease.

机构信息

a Broad Institute ; Cambridge , MA USA.

b Center for Computational and Integrative Biology ; Massachusetts General Hospital ; Boston , MA USA.

出版信息

Autophagy. 2018;14(2):216-220. doi: 10.1080/15548627.2017.1389358. Epub 2018 Jan 29.

DOI:10.1080/15548627.2017.1389358
PMID:29130415
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5902220/
Abstract

The discovery of numerous genetic variants in the human genome that are associated with inflammatory bowel disease (IBD) has revealed critical pathways that play important roles in intestinal homeostasis. These genetic studies have identified a critical role for macroautophagy/autophagy and more recently, lysosomal function, in maintaining the intestinal barrier and mucosal homeostasis. This review highlights recent work on the functional characterization of IBD-associated human genetic variants in cell type-specific functions for autophagy.

摘要

人类基因组中发现的许多与炎症性肠病 (IBD) 相关的遗传变异揭示了在肠道稳态中发挥重要作用的关键途径。这些遗传研究表明，巨自噬/自噬作用，以及最近溶酶体功能，在维持肠道屏障和黏膜稳态方面发挥着关键作用。本文综述了最近在细胞类型特异性自噬功能方面对 IBD 相关人类遗传变异的功能特征分析的工作。

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本文引用的文献

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Science. 2017 Sep 8;357(6355):1047-1052. doi: 10.1126/science.aal4677. Epub 2017 Jul 27.
2
Lack of Prenylated Proteins, Autophagy Impairment and Apoptosis in SH-SY5Y Neuronal Cell Model of Mevalonate Kinase Deficiency.甲羟戊酸激酶缺乏症的SH-SY5Y神经元细胞模型中异戊二烯化蛋白缺乏、自噬受损与细胞凋亡
Cell Physiol Biochem. 2017;41(4):1649-1660. doi: 10.1159/000471235. Epub 2017 Mar 28.
3
Regulated in development and DNA damage responses 1 (REDD1) links stress with IL-1β-mediated familial Mediterranean fever attack through autophagy-driven neutrophil extracellular traps.发育调节和 DNA 损伤反应蛋白 1（REDD1）通过自噬驱动的中性粒细胞胞外诱捕网将应激与白细胞介素-1β介导的家族性地中海热发作联系起来。
J Allergy Clin Immunol. 2017 Nov;140(5):1378-1387.e13. doi: 10.1016/j.jaci.2017.02.021. Epub 2017 Mar 23.
4
Lysosomal cholesterol activates mTORC1 via an SLC38A9-Niemann-Pick C1 signaling complex.溶酶体胆固醇通过SLC38A9-尼曼-皮克病C1型信号复合物激活mTORC1。
Science. 2017 Mar 24;355(6331):1306-1311. doi: 10.1126/science.aag1417.
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Rip2 Is Required for Nod2-Mediated Lysozyme Sorting in Paneth Cells.潘氏细胞中Nod2介导的溶菌酶分选需要Rip2。
J Immunol. 2017 May 1;198(9):3729-3736. doi: 10.4049/jimmunol.1601583. Epub 2017 Mar 22.
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The Ubiquitin Binding Protein TAX1BP1 Mediates Autophagasome Induction and the Metabolic Transition of Activated T Cells.泛素结合蛋白TAX1BP1介导自噬体的诱导及活化T细胞的代谢转变。
Immunity. 2017 Mar 21;46(3):405-420. doi: 10.1016/j.immuni.2017.02.018. Epub 2017 Mar 14.
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