Lai Shih-Wei, Lin Cheng-Li, Liao Kuan-Fu
College of Medicine, China Medical University, Taichung 404, Taiwan - Department of Family Medicine, China Medical University Hospital, Taichung 404, Taiwan.
College of Medicine, China Medical University, Taichung 404, Taiwan - Management Office for Health Data, China Medical University Hospital, Taichung 404, Taiwan.
Biomedicine (Taipei). 2017 Dec;7(4):26. doi: 10.1051/bmdcn/2017070426. Epub 2017 Nov 13.
Few systematic studies focus on the association between weight loss and pyogenic liver abscesses. The objective of the study was to assess the association between weight loss and pyogenic liver abscesses in adults in Taiwan.
This population-based cohort study utilized the database of the Taiwan National Health Insurance Program. Totally, 8453 subjects aged 20 to 84 years with newly diagnosed weight loss between 2000 and 2012 were assigned as the weight loss group, and 33777 randomly selected subjects without weight loss were assigned as the non-weight loss group. Both the weight loss and the non-weight loss groups were matched according to sex, age, and comorbidities. The incidence of pyogenic liver abscesses at the end of 2013 was measured in both groups.
A multivariable Cox proportional hazards regression model was done and presented evidence that the adjusted HR of pyogenic liver abscess was 2.47 (95 %CI 1.21, 5.02) for those subjects with weight loss and without comorbidities, as compared with those subjects without weight loss and without comorbidities. Among the weight loss group, 5% developed pyogenic liver abscesses within 3 months.
Weight loss is associated with pyogenic liver abscesses in adults. Yet weight loss might not be an early clinical symptom of undiagnosed pyogenic liver abscesses.
很少有系统性研究关注体重减轻与化脓性肝脓肿之间的关联。本研究的目的是评估台湾成年人中体重减轻与化脓性肝脓肿之间的关联。
这项基于人群的队列研究利用了台湾国民健康保险计划的数据库。2000年至2012年间，共有8453名年龄在20至84岁之间、新诊断出体重减轻的受试者被分配到体重减轻组，33777名随机选择的无体重减轻的受试者被分配到非体重减轻组。体重减轻组和非体重减轻组均根据性别、年龄和合并症进行匹配。测量两组在2013年底化脓性肝脓肿的发病率。
进行了多变量Cox比例风险回归模型分析，结果表明，与无体重减轻且无合并症的受试者相比，无合并症的体重减轻受试者发生化脓性肝脓肿的校正风险比为2.47（95%可信区间1.21，5.02）。在体重减轻组中，5%的人在3个月内发生了化脓性肝脓肿。
体重减轻与成年人化脓性肝脓肿有关。然而，体重减轻可能不是未确诊化脓性肝脓肿的早期临床症状。
