Department of Psychiatry and Amsterdam Public Health Research Institute, Amsterdam, The Netherlands.
Psychother Psychosom. 2017;86(6):362-369. doi: 10.1159/000480456. Epub 2017 Nov 3.
Antidepressant use is highly prevalent. Research has mainly focused on efficacy during short periods of use for depression and anxiety. There is a relative paucity of data regarding the frequency of long-term use.
To determine the prevalence and possible increase of long-term use of antidepressants over recent years, we analyzed routine general practice care data in a large cohort of patients (n = 156,620) in and around Amsterdam, The Netherlands. Additionally, predictors of long-term use were studied.
Prevalence of long-term use of antidepressants is substantial, and such use appears to be increasing: 30.3% of use was long-term over the period 1995-2005 compared to 43.7% for the period 2005-2015. Higher age, a registered diagnosis of anxiety or depression, and the use of SSRIs or SNRIs were associated with long-term use in multivariate analysis. In addition, specific antidepressants were differentially associated with long-term use.
Long-term antidepressant use is substantial and appears to be on the rise. Awareness of this phenomenon should be increased, such use should be prevented when possible, and reasons for long-term use need to be examined.
抗抑郁药的使用非常普遍。研究主要集中在短期使用治疗抑郁和焦虑方面的疗效上。关于长期使用的频率，相关数据相对较少。
为了确定近年来长期使用抗抑郁药的流行率和可能的增加，我们分析了荷兰阿姆斯特丹及周边地区一个大型患者队列（n=156620）的常规全科医疗数据。此外，还研究了长期使用的预测因素。
长期使用抗抑郁药的比例相当高，而且这种使用似乎在增加：1995 年至 2005 年期间，长期使用的比例为 30.3%，而 2005 年至 2015 年期间则为 43.7%。多变量分析显示，年龄较大、焦虑或抑郁的登记诊断、SSRIs 或 SNRIs 的使用与长期使用相关。此外，特定的抗抑郁药与长期使用有不同的相关性。
长期使用抗抑郁药的比例相当高，而且似乎呈上升趋势。应该提高对这种现象的认识，尽可能预防这种使用，并需要检查长期使用的原因。
