The relationship between ischaemia-modified albumin and good coronary collateral circulation.

BACKGROUND

It is important to determine the grade of the coronary collateral circulation (CCC) in patients with stable coronary artery disease.

AIM

In this study, we aimed to investigate the relationship between the ischaemia-modified albumin (IMA) level and good CCC.

METHODS

A total of 95 patients with coronary angiography and at least one epicardial coronary artery obstruction were included in the study. The Rentrop classification was used with CCC grading, where 0 and 1 were defined as poor collateral, and 2 and 3 were defined as good collateral. The IMA level of the patients was measured using an enzyme-linked immunosorbent assay (ELISA). The receiver-operating characteristic curve was used to show the sensitivity and specificity of IMA levels and the optimal cut-off value for predicting good CCC.

RESULTS

The multiple logistic regression analysis revealed that the IMA level in the good CCC group was higher (p < 0.045). Conversely, the high-sensitivity C-reactive protein level was lower in the good CCC group (p < 0.023). We found an IMA cut-off value (4.7 ng/mL) that indicated good CCC level, and this shows good CCC with 70.2% sensitivity and 60.3% specificity.

CONCLUSIONS

The IMA level could serve as a simple and useful predictor of well-developed CCC.