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食物蛋白诱导的小肠结肠炎综合征

Food Protein-Induced Enterocolitis Syndrome.

作者信息

Bingemann Theresa A, Sood Puja, Järvinen Kirsi M

机构信息

Allergy, Immunology and Rheumatology, Rochester Regional Health, 222 Alexander Street, Suite 3000, Rochester, NY 14607, USA; Division of Pediatric Allergy and Immunology, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA.

Division of Pediatric Allergy and Immunology, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA.

出版信息

Immunol Allergy Clin North Am. 2018 Feb;38(1):141-152. doi: 10.1016/j.iac.2017.09.009. Epub 2017 Oct 26.

Abstract

Food protein-induced enterocolitis syndrome (FPIES) is a non-IgE-mediated food allergy that usually presents in infancy. Cow's milk, soy, and grains are the most common food triggers. FPIES can present as a medical emergency with symptoms including delayed persistent emesis or diarrhea that can lead to severe dehydration and hemodynamic instability with abnormal laboratory markers. Diagnosis can often be made based on clinical history and noted improvement in symptoms once the suspected triggers have been removed from the diet, with oral food challenge as the gold standard for confirmation of diagnosis in unclear cases.

摘要

食物蛋白诱导的小肠结肠炎综合征(FPIES)是一种非IgE介导的食物过敏,通常在婴儿期出现。牛奶、大豆和谷物是最常见的触发食物。FPIES可表现为医疗急症,症状包括延迟性持续性呕吐或腹泻,可导致严重脱水和血流动力学不稳定,并伴有异常的实验室指标。诊断通常可根据临床病史以及在从饮食中去除疑似触发食物后症状明显改善来做出,在不明确的病例中,口服食物激发试验是确诊的金标准。

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