中性粒细胞与淋巴细胞比值预测急性冠状动脉综合征的死亡率和主要不良心脏事件：一项系统评价和荟萃分析。
Neutrophil to lymphocyte ratio predict mortality and major adverse cardiac events in acute coronary syndrome: A systematic review and meta-analysis.
作者信息
Dong Chao-Hui, Wang Zhang-Min, Chen Si-Yu
机构信息
Department of Cardio-Pulmonary Rehabilitation, The Affiliated Rehabilitation Hospital of Chongqing Medical University, China.
Department of Vascular Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
出版信息
Clin Biochem. 2018 Feb;52:131-136. doi: 10.1016/j.clinbiochem.2017.11.008. Epub 2017 Nov 11.
OBJECTIVES
Neutrophil to lymphocyte ratio (NLR) might be associated with the mortality or major adverse cardiac events (MACEs) in acute coronary syndrome (ACS) patients. We performed a meta-analysis to evaluate the correlation between NLR and mortality/MACEs in ACS.
METHODS
We assessed clinical trials through Pubmed, EMBASE, the Cochrane Library and Web of science in investigating the association between NLR and mortality/MACEs in ACS patients up to August 15, 2017. The primary outcome was mortality or recurrent MACEs.
RESULTS
In total, 8 studies of 9406 patients were included in the systematic and meta-analysis. Our analysis indicated that elevated pretreatment NLR was a poor prognostic marker for patients with recent ACS in predicting medium to long-term mortality/MACEs (OR 1.26, 95%CI 1.13-1.41). And the analysis indicated that higher pretreatment NLR value was associated with higher in-hospital mortality in ACS patients (OR 6.39, 95%CI 1.49-27.38, p<0.001). The NLR value of 5.0 maybe a cut-off value for ACS risk.
CONCLUSIONS
In patients with a recent ACS, an elevated pretreatment NLR value is effective in predicting the risk of mortality/MACEs.
目的
中性粒细胞与淋巴细胞比值（NLR）可能与急性冠状动脉综合征（ACS）患者的死亡率或主要不良心脏事件（MACE）相关。我们进行了一项荟萃分析，以评估NLR与ACS患者死亡率/MACE之间的相关性。
方法
我们通过PubMed、EMBASE、Cochrane图书馆和科学网评估临床试验，以调查截至2017年8月15日NLR与ACS患者死亡率/MACE之间的关联。主要结局是死亡率或复发性MACE。
结果
系统评价和荟萃分析共纳入8项研究，涉及9406例患者。我们的分析表明，在预测中长期死亡率/MACE方面，ACS患者治疗前NLR升高是不良预后指标（OR 1.26，95%CI 1.13-1.41）。分析还表明，ACS患者治疗前NLR值越高，住院死亡率越高（OR 6.39，95%CI 1.49-27.38，p<0.001）。NLR值5.0可能是ACS风险的临界值。
结论
在近期ACS患者中，治疗前NLR值升高可有效预测死亡率/MACE风险。
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