Liu Weili, Zhu Mei, Yu Zhongwang, Yin Dou, Lu Fengfeng, Pu Yingyan, Zhao Chao, He Cheng, Cao Li
Institute of Health Sciences, Anhui University, Hefei 230601, China; Institute of Neuroscience, Key Laboratory of Molecular Neurobiology of the Ministry of Education and the Collaborative Innovation Center for Brain Science, Second Military Medical University, Shanghai 200433, China.
Institute of Neuroscience, Key Laboratory of Molecular Neurobiology of the Ministry of Education and the Collaborative Innovation Center for Brain Science, Second Military Medical University, Shanghai 200433, China.
J Neuroimmunol. 2017 Dec 15;313:152-160. doi: 10.1016/j.jneuroim.2017.10.018. Epub 2017 Oct 31.
Multiple sclerosis (MS) is a chronic autoimmune demyelinating disease of the central nervous system. Currently, there is no drug available to cure this kind of disease. Diosgenin is a plant-derived steroid saponin. A previous study in our lab revealed that diosgenin can promote oligodendrocyte progenitor cell differentiation and accelerate remyelination. In the present study, we found that diosgenin dose-dependently alleviated the progression of experimental autoimmune encephalomyelitis with reduced central nervous system inflammation and demyelination. We also found that diosgenin treatment can significantly inhibit the activation of microglia and macrophages, suppress CD4 T cell proliferation and hinder Th1/Th17 cell differentiation. Therefore, we suggested that diosgenin may be a potential therapeutic drug for inflammatory demyelinating diseases, such as MS.
多发性硬化症（MS）是一种中枢神经系统的慢性自身免疫性脱髓鞘疾病。目前，尚无药物可治愈此类疾病。薯蓣皂苷元是一种植物来源的甾体皂苷。我们实验室之前的一项研究表明，薯蓣皂苷元可促进少突胶质前体细胞分化并加速髓鞘再生。在本研究中，我们发现薯蓣皂苷元呈剂量依赖性地减轻实验性自身免疫性脑脊髓炎的进展，同时减轻中枢神经系统炎症和脱髓鞘。我们还发现，薯蓣皂苷元治疗可显著抑制小胶质细胞和巨噬细胞的激活，抑制CD4 T细胞增殖并阻碍Th1/Th17细胞分化。因此，我们认为薯蓣皂苷元可能是一种用于治疗诸如MS等炎性脱髓鞘疾病的潜在治疗药物。
