利妥昔单抗和环磷酰胺联合半相合 T 细胞强化移植后发生进行性多灶性白质脑病：病例报告及文献复习
Progressive multifocal leukoencephalopathy in patients receiving rituximab and cyclophosphamide after haplo-identical T-cell replete transplantation and review of the literature.
机构信息
Bone Marrow Transplantation Program, Department of Internal Medicine, American University of Beirut, Beirut, Lebanon.
Infectious Disease, Department of Internal Medicine, American University of Beirut, Beirut, Lebanon.
出版信息
Curr Res Transl Med. 2017 Nov;65(4):127-132. doi: 10.1016/j.retram.2017.10.002. Epub 2017 Nov 10.
John Cunningham virus (JCV) reactivation, occurring mainly in immunocompromised patients, leads to progressive multifocal leukoencephalopathy, an uncommon but lethal disease. JCV reactivation after T-cell replete haploidentical stem cell transplantation, in the pre-cyclophosphamide era, is poorly represented in the literature. We therefore describe two cases of acute myeloid leukemia who developed JCV reactivation after receiving cyclophosphamide and rituximab post haploidentical stem cell transplantation, and review the literature, aiming to a better understanding of the disease course and its risk factors.
JC 病毒（JCV）激活主要发生于免疫功能低下的患者，可导致进行性多灶性白质脑病，这是一种罕见但致命的疾病。在环磷酰胺时代之前，T 细胞丰富的单倍体造血干细胞移植后 JCV 激活在文献中报道较少。因此，我们描述了 2 例接受环磷酰胺和利妥昔单抗治疗后发生 JCV 激活的急性髓系白血病患者，并对文献进行了回顾，旨在更好地了解疾病过程及其危险因素。
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