Synthesis and radioprotective activity of dipeptide cysteamine and cystamine derivatives.
作者信息
Oiry J, Pue J Y, Imbach J L, Fatome M, Sentenac-Roumanou H
机构信息
Laboratoire de Chimie Bio-Organique, U.A. 488 du CNRS, Université des Sciences et Techniques du Languedoc, Montpellier, France.
出版信息
J Med Chem. 1989 Feb;32(2):297-301. doi: 10.1021/jm00122a004.
PMID:2913293
Abstract
Some N-(dipeptidyl)-S-acetylcysteamine and N,N'-(dipeptidyl)cystamine salt derivatives were synthesized and evaluated as candidate radioprotector agents. Toxicity and radioprotective activity as the dose reduction factor (DRF) were determined in vivo on mice and compared to N-glycyl-S-acetylcysteamine trifluoroacetate. One of the most interesting compounds of this series was N-glycylglycyl-S-acetylcysteamine trifluoroacetate (8).
摘要
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