半乳糖凝集素-3：损伤大脑中小胶质细胞反应的介质。
Galectin-3: mediator of microglia responses in injured brain.
机构信息
Department of Psychiatry and Neuroscience, Faculty of Medicine, CERVO Brain Research Center, Laval University, Quebec, Quebec G1J 2G3, Canada.
Department of Psychiatry and Neuroscience, Faculty of Medicine, CERVO Brain Research Center, Laval University, Quebec, Quebec G1J 2G3, Canada; Faculty of Medicine, Department of Psychiatry and Neuroscience, Laval University, Québec, Québec, Canada.
出版信息
Drug Discov Today. 2018 Feb;23(2):375-381. doi: 10.1016/j.drudis.2017.11.004. Epub 2017 Nov 10.
Galectin-3 is a pleiotropic protein involved in cell activation, proliferation and migration and plays a pivotal part as an inflammatory mediator in neurodegeneration. Galectin-3 is associated with microglial activation and proliferation after ischemia. Given its putative role as a dynamic fine-tuner of microglia, activation of Galectin-3 provides molecular cues in design of new immunomodulatory strategies for stroke management. This review summarizes recent evidence on the role of Galectin-3 as a mediator of immune responses in damaged brain and mechanisms employed by Galectin-3 to affect microglial function.
半乳糖凝集素-3 是一种多功能蛋白，参与细胞的激活、增殖和迁移，作为神经退行性变中的炎症介质发挥关键作用。半乳糖凝集素-3 与缺血后小胶质细胞的激活和增殖有关。鉴于其作为小胶质细胞动态微调因子的潜在作用，半乳糖凝集素-3 的激活为设计用于脑卒中管理的新型免疫调节策略提供了分子线索。本综述总结了半乳糖凝集素-3 作为受损大脑中免疫反应介质的作用以及半乳糖凝集素-3 影响小胶质细胞功能的机制的最新证据。
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