Tanır Yaşar, Gülle Zeynep Nur, Uncu Gökçe Sultan, Baki Adile Merve, Vural Pervin, Soylu Nusret, Örengül Abdurrahman Cahid
Department of Child and Adolescent Psychiatry, Istanbul Medical Faculty, Istanbul University, Istanbul, Türkiye.
Department of Child and Adolescent Psychiatry, University of Health Science Van Training and Research Hospital, Van, Türkiye.
Psychiatry Investig. 2023 Jul;20(7):609-615. doi: 10.30773/pi.2023.0048. Epub 2023 Jul 7.
Specific learning disorder (SLD) is a neurodevelopmental disorder in which underlying pathogenesis and etiological factors are not fully understood. Neuroinflammatory response (measured with serum levels of galectin-1 and galectin-3), which is associated with learning and memory, may play an important role in the etiopathogenesis of SLD. Aim of the present study is to examine whether serum galectin-1 and galectin-3 levels are related to SLD.
The current study consisted of 42 treatment-naive children with SLD and 42 control subjects. All of the subjects were assessed using semi-structured psychiatric examination to diagnose SLD and exclude attention-deficit hyperactivity disorder. Serum galectin-1 and galectin-3 levels were measured via venous blood samples.
The SLD and control group did not differ significantly in terms of age, sex, and body mass index (BMI). The SLD group had significantly higher serum levels of galectin-1 (8.78±2.97 vs. 7.40±2.03, p=0.019) and galectin-3 (1.86±0.93 vs. 1.32±0.69, p=0.003) than the control group when controlled for age, sex, and BMI.
Higher serum levels of galectin-1 and galectin-3 in children with SLD may indicate the role of neuroinflammatory response in the pathogenesis of SLD. Other mechanisms involving galectin-1 and galectin-3 related to learning may play a part in the etiology of SLD.
特定学习障碍（SLD）是一种神经发育障碍，其潜在的发病机制和病因尚未完全明确。与学习和记忆相关的神经炎症反应（通过血清半乳糖凝集素-1和半乳糖凝集素-3水平来衡量）可能在SLD的病因发病机制中起重要作用。本研究的目的是探讨血清半乳糖凝集素-1和半乳糖凝集素-3水平是否与SLD相关。
本研究纳入了42例未经治疗的SLD儿童和42例对照受试者。所有受试者均通过半结构化精神检查进行评估，以诊断SLD并排除注意力缺陷多动障碍。通过静脉血样检测血清半乳糖凝集素-1和半乳糖凝集素-3水平。
SLD组和对照组在年龄、性别和体重指数（BMI）方面无显著差异。在控制年龄、性别和BMI后，SLD组的血清半乳糖凝集素-1水平（8.78±2.97 vs. 7.40±2.03，p=0.019）和半乳糖凝集素-3水平（1.86±0.93 vs. 1.32±0.69，p=0.003）显著高于对照组。
SLD儿童血清半乳糖凝集素-1和半乳糖凝集素-3水平较高可能表明神经炎症反应在SLD发病机制中的作用。涉及半乳糖凝集素-1和半乳糖凝集素-3与学习相关的其他机制可能在SLD的病因中起作用。
