Edelstein M B
Section of Hematology and Oncology, Veterans Administration Medical Center, Allen Park, MI 48101.
J Natl Cancer Inst. 1989 Feb 15;81(4):298-301. doi: 10.1093/jnci/81.4.298.
The dose and schedule requirements found for the combination of L-histidinol and 5-fluorouracil (5-FU) were concordant with those for the combination of L-histidinol and cisplatin. Furthermore, cisplatin-L-histidinol was active against colon 26 tumor, an adenocarcinoma that developed in a BALB/c female mouse and that has been grown as a solid tumor. The toxicity of cisplatin was prevented only when cisplatin was given before L-histidinol. Studies of L-histidinol and 5-FU had similar results. For (DBA/2 X BALB/c)F1 mice, 50 mg of L-histidinol per mouse was required for protection; for hematopoietic precursor cells, protection was dependent on the dose of L-histidinol. In contrast, both L1210 leukemia cells and colon 26 adenocarcinoma cells were more efficiently killed by combinations of L-histidinol and cisplatin. This effect depended on the doses of L-histidinol and cisplatin, a finding similar to the finding for hematopoietic precursor cells.
L-组氨醇与5-氟尿嘧啶（5-FU）联合使用时所需的剂量和给药方案与L-组氨醇和顺铂联合使用时一致。此外，顺铂-L-组氨醇对结肠26肿瘤具有活性，该肿瘤是在一只BALB/c雌性小鼠中发生的腺癌，已作为实体瘤生长。只有当顺铂在L-组氨醇之前给药时，顺铂的毒性才能得到预防。L-组氨醇和5-FU的研究也有类似结果。对于（DBA/2×BALB/c）F1小鼠，每只小鼠需要50mg的L-组氨醇来提供保护；对于造血前体细胞，保护作用取决于L-组氨醇的剂量。相比之下，L-组氨醇和顺铂的联合使用能更有效地杀死L1210白血病细胞和结肠26腺癌细胞。这种效应取决于L-组氨醇和顺铂的剂量，这一发现与造血前体细胞的发现相似。
