药物重定位在胶质母细胞瘤中的应用
Drug Repositioning Meets Precision in Glioblastoma.
机构信息
Neurology Clinic, University of Heidelberg, Heidelberg, Germany.
Clinical Cooperation Unit (CCU) Neurooncology, German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.
出版信息
Clin Cancer Res. 2018 Jan 15;24(2):256-258. doi: 10.1158/1078-0432.CCR-17-2989. Epub 2017 Nov 13.
Glioblastoma has a gigantic unmet medical need. Molecular knowledge has evolved substantially, including data on clonal selection with progression. Past trials for all-comers may have produced false negative results. Molecular precision at progression needs workup of new tissue, and revisiting drugs with a focus on brain tumor penetration may yield surprises. .
胶质母细胞瘤存在巨大的未满足的医疗需求。分子知识已经有了很大的发展，包括关于克隆选择与进展的数据。过去针对所有患者的试验可能产生了假阴性结果。进展时的分子精准治疗需要对新组织进行检测，重新关注具有脑肿瘤穿透性的药物可能会带来惊喜。
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