Proudfoot Owen
Bio-organic and Medicinal Chemistry Laboratory, Centre for Biomedical Research, Burnet Institute, Melbourne University, Melbourne, Victoria, Australia.
Neurol India. 2017 Nov-Dec;65(6):1241-1247. doi: 10.4103/0028-3886.217949.
The collective evidence to date suggests that environmental exposure to excessive amounts of manganese (Mn) can cause a neurodegenerative condition known as manganism. It is now also relatively clear that Mn is involved in the pathogenesis of Alzheimer's disease and at least some prion diseases. The potential involvement of Mn in a panel of other neurodegenerative conditions including Parkinson's disease, Huntington's disease, amyotrophic lateral sclerosis, and Batten disease has been suggested and investigated, but the results to date are somewhat inconclusive. Herein, previously reported experimental studies investigating the involvement of Mn in the pathogenesis of these conditions are narratively reviewed.
迄今为止的综合证据表明，环境中接触过量的锰（Mn）会导致一种称为锰中毒的神经退行性疾病。现在也相对清楚的是，锰与阿尔茨海默病和至少一些朊病毒病的发病机制有关。有人提出并研究了锰可能与包括帕金森病、亨廷顿病、肌萎缩侧索硬化症和巴滕病在内的一系列其他神经退行性疾病有关，但迄今为止的结果尚无定论。在此，对先前报道的研究锰在这些疾病发病机制中作用的实验研究进行叙述性综述。
