Thoracic Oncology Program, Earle A Chiles Research Institute, 7400 SW Barnes Rd. A242, Portland, OR, 97225 -7007, USA.
Fariborz Maseeh Department of Mathematics and Statistics, Portland State University, Portland, OR, USA.
Lung. 2018 Feb;196(1):125-127. doi: 10.1007/s00408-017-0070-x. Epub 2017 Nov 13.
The incidence of three granulomatous response diseases-sarcoidosis, tuberculosis, and non-tuberculous mycobacterial pulmonary disease-differ markedly in African-Americans versus Caucasians. In reviewing a large compendium of non-cystic-fibrosis bronchiectasis, we noted that complicating infection with non-tuberculous mycobacteria was relatively infrequent among individuals of African-American descent, confirming previous observations of their inherent resistance. Disease-specific variance among African-Americans in the efficacy of their granulomatous response suggests a nexus, a mediating, immunological mechanism. Environmentally conditioned selection of SLC11A1 (Nramp1) alleles may account for this ethnic variance.
三种肉芽肿反应疾病（结节病、结核病和非结核分枝杆菌肺病）在非裔美国人和白种人中的发病率差异显著。在回顾大量非囊性纤维化支气管扩张症的资料时，我们注意到，非结核分枝杆菌感染在非洲裔美国人中相对较少见，这证实了他们先天耐药的先前观察结果。在非裔美国人中，其肉芽肿反应的疗效存在疾病特异性差异，这表明存在一个关联，一种介导的免疫机制。SLC11A1（NRAMP1）等位基因的环境条件选择可能解释了这种种族差异。
