2nd Department of Nephrology and Hypertension with Dialysis Unit, Medical University of Bialystok, Marii Skłodowskiej-Curie 24a, 15-276, Białystok, Poland.
Department of Allergy and Internal Medicine, Medical University of Bialystok, Białystok, Poland.
Int Urol Nephrol. 2018 Jan;50(1):121-125. doi: 10.1007/s11255-017-1741-5. Epub 2017 Nov 13.
BACKGROUND/AIMS: Zonulin is the only known regulator of intestinal permeability. It is also considered as a potential inflammatory marker in several conditions such as diabetes and inflammatory bowel syndrome. The aim of the study was to investigate zonulin levels in patients with early stages of CKD and its possible correlation with inflammation, anemia and iron status parameters.
Eighty-eight patients with early stages of CKD and 23 healthy volunteers were enrolled in the study. Zonulin, hepcidin-25, soluble transferrin receptor, interleukin-6 and high-sensitivity C-reactive protein were measured using commercially available assays.
Zonulin was significantly lower among patients with CKD in comparison with healthy volunteers. There were no statistically significant differences in zonulin concentration between patients with and without inflammation. Zonulin was significantly correlated with hepcidin only in patients with inflammation. Zonulin was neither related to iron nor related to ferritin.
Zonulin cannot be considered as an inflammatory marker in CKD. It does not play a role in the disturbances of iron metabolism in CKD. Its physiological role remains to be elucidated.
背景/目的：肠通透素是唯一已知的肠道通透性调节剂。它也被认为是几种情况下的潜在炎症标志物，如糖尿病和炎症性肠病。本研究的目的是调查早期慢性肾脏病患者的肠通透素水平及其与炎症、贫血和铁状态参数的可能相关性。
本研究纳入了 88 例早期慢性肾脏病患者和 23 名健康志愿者。使用商业上可用的检测方法测量肠通透素、hepcidin-25、可溶性转铁蛋白受体、白细胞介素-6 和高敏 C 反应蛋白。
与健康志愿者相比，慢性肾脏病患者的肠通透素明显降低。有炎症和无炎症的患者之间，肠通透素浓度无统计学差异。只有在有炎症的患者中，肠通透素与 hepcidin 显著相关。肠通透素与铁或铁蛋白均无相关性。
在慢性肾脏病中，肠通透素不能被视为炎症标志物。它在慢性肾脏病中铁代谢紊乱中不起作用。其生理作用仍有待阐明。
