Doll D C, Ringenberg Q S, Anderson S P, Hewett J E, Yarbro J W
Department of Medicine, University of Missouri, Columbia.
Med Pediatr Oncol. 1989;17(1):1-5. doi: 10.1002/mpo.2950170102.
Results of bone marrow biopsy were retrospectively evaluated in 120 previously untreated patients with Hodgkin's disease. The incidence of bone marrow involvement was 13%. All patients with marrow invasion had B symptoms and/or clinically advanced disease. When patients with bone marrow involvement were compared to those without there were significant differences in the incidence of B symptoms, the clinical stage, hemoglobin levels, leukocyte counts, platelet counts, and serum levels of lactate dehydrogenase and alkaline phosphatase. None of 59 patients with clinical stage IA and IIA had evidence of marrow invasion. This study demonstrates that trephine bone marrow biopsy is of value in detecting marrow involvement in specific subgroups of untreated patients with Hodgkin's disease, i.e., those patients with constitutional symptoms and/or clinical stage III or IV. However, bone marrow biopsy adds little to the initial staging of patients with clinical stage IA and IIA. Routine use of this procedure in such patients may be unnecessary.
对120例未经治疗的霍奇金病患者的骨髓活检结果进行了回顾性评估。骨髓受累发生率为13%。所有骨髓侵犯患者均有B症状和/或临床晚期疾病。将有骨髓受累的患者与无骨髓受累的患者进行比较时，B症状发生率、临床分期、血红蛋白水平、白细胞计数、血小板计数以及乳酸脱氢酶和碱性磷酸酶的血清水平存在显著差异。59例临床分期为IA和IIA期的患者均无骨髓侵犯证据。本研究表明，骨髓穿刺活检对于检测未经治疗的霍奇金病特定亚组患者，即有全身症状和/或临床分期为III或IV期的患者的骨髓受累有价值。然而，骨髓活检对临床分期为IA和IIA期患者的初始分期作用不大。在此类患者中常规使用该检查可能没有必要。
