Weir A B, Dow L W
Department of Medicine, St. Jude Children's Research Hospital, Memphis, Tennessee.
Med Pediatr Oncol. 1989;17(1):58-61. doi: 10.1002/mpo.2950170112.
A patient with chronic lymphocytic leukemia presented with recurrent episodes of severe neutropenia. This neutropenia was initially responsive to prednisone but eventually became refractory. A spindle-cell thymoma was diagnosed and resected with dramatic improvement in his granulocytopenia. Both autologous and heterologous granulocyte macrophage colony growth were clearly inhibited by the patient's serum. This is the first reported case of severe granulocytopenia associated with a thymoma that seemed to be reversed following thymectomy.
一名慢性淋巴细胞白血病患者出现反复严重中性粒细胞减少发作。这种中性粒细胞减少最初对泼尼松有反应，但最终变得难治。诊断出梭形细胞胸腺瘤并进行了切除，其粒细胞减少症有显著改善。患者血清明显抑制自体和异源粒细胞巨噬细胞集落生长。这是首例报道的与胸腺瘤相关的严重粒细胞减少症，在胸腺切除术后似乎得到逆转的病例。
