The 11th C2H2 zinc finger and an adjacent C-terminal arm are responsible for TZAP recognition of telomeric DNA.
作者信息
Zhao Yaqing, Zhang Guang, He Chao, Mei Yide, Shi Yunyu, Li Fudong
机构信息
Hefei National Laboratory for Physical Sciences at Microscale and School of Life Sciences, University of Science and Technology of China, Hefei, Anhui 230026, China.
Anhui Key Laboratory of Modern Biomanufacturing and School of Life Sciences, Anhui University, Hefei, Anhui 230601, China.
出版信息
Cell Res. 2018 Jan;28(1):130-134. doi: 10.1038/cr.2017.141. Epub 2017 Nov 14.
Abstract
摘要
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本文引用的文献
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EMBO Rep. 2017 Jun;18(6):929-946. doi: 10.15252/embr.201744095. Epub 2017 May 12.
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TZAP-ing telomeres down to size.TZAP 技术可将端粒缩小至合适尺寸。
EMBO Rep. 2017 Jun;18(6):861-863. doi: 10.15252/embr.201744354. Epub 2017 May 12.
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TZAP or not to zap telomeres.是否破坏端粒
Science. 2017 Feb 10;355(6325):578-579. doi: 10.1126/science.aam7015.
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A balance between elongation and trimming regulates telomere stability in stem cells.延伸与修剪之间的平衡调节干细胞中的端粒稳定性。
Nat Struct Mol Biol. 2017 Jan;24(1):30-39. doi: 10.1038/nsmb.3335. Epub 2016 Dec 5.
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Normal mammalian cells negatively regulate telomere length by telomere trimming.正常的哺乳动物细胞通过端粒修剪来负调控端粒长度。
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