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The 11th C2H2 zinc finger and an adjacent C-terminal arm are responsible for TZAP recognition of telomeric DNA.第11个C2H2锌指结构和相邻的C末端臂负责TZAP对端粒DNA的识别。
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Zbtb48 is a regulator of Mtfp1 expression in zebrafish.Zbtb48是斑马鱼中Mtf1p表达的调节因子。
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A universal method for the purification of C2H2 zinc finger arrays.一种纯化C2H2锌指阵列的通用方法。
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Structural basis for C. elegans pairing center DNA binding specificity by the ZIM/HIM-8 family proteins.ZIM/HIM-8 家族蛋白介导的秀丽隐杆线虫配对中心 DNA 结合特异性的结构基础。
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ZBTB48 is a priming factor regulating B-cell-specific CIITA expression.ZBTB48是一种调节B细胞特异性CIITA表达的启动因子。
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ZNF524 directly interacts with telomeric DNA and supports telomere integrity.ZNF524 与端粒 DNA 直接相互作用,支持端粒的完整性。
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TZAP overexpression induces telomere dysfunction and ALT-like activity in ATRX/DAXX-deficient cells.TZAP的过表达在ATRX/DAXX缺陷细胞中诱导端粒功能障碍和ALT样活性。
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Zinc finger and SCAN domain containing 1, ZSCAN1, is a novel stemness-related tumor suppressor and transcriptional repressor in breast cancer targeting TAZ.含锌指和SCAN结构域蛋白1(ZSCAN1)是一种新型的与干性相关的肿瘤抑制因子,也是乳腺癌中靶向TAZ的转录抑制因子。
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9
Structural insights into the recognition of telomeric variant repeat TTGGGG by broad-complex, tramtrack and bric-à-brac - zinc finger protein ZBTB10.结构洞察广泛复杂、tramtrack 和 bric-à-brac - 锌指蛋白 ZBTB10 对端粒变体重复 TTGGGG 的识别。
J Biol Chem. 2023 Mar;299(3):102918. doi: 10.1016/j.jbc.2023.102918. Epub 2023 Jan 16.
10
Telomeres and Telomerase in the Control of Stem Cells.干细胞调控中的端粒与端粒酶
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本文引用的文献

1
ZBTB48 is both a vertebrate telomere-binding protein and a transcriptional activator.锌指和BTB结构域蛋白48(ZBTB48)既是一种脊椎动物端粒结合蛋白,也是一种转录激活因子。
EMBO Rep. 2017 Jun;18(6):929-946. doi: 10.15252/embr.201744095. Epub 2017 May 12.
2
TZAP-ing telomeres down to size.TZAP 技术可将端粒缩小至合适尺寸。
EMBO Rep. 2017 Jun;18(6):861-863. doi: 10.15252/embr.201744354. Epub 2017 May 12.
3
TZAP or not to zap telomeres.是否破坏端粒
Science. 2017 Feb 10;355(6325):578-579. doi: 10.1126/science.aam7015.
4
TZAP: A telomere-associated protein involved in telomere length control.TZAP:一种参与端粒长度调控的端粒相关蛋白。
Science. 2017 Feb 10;355(6325):638-641. doi: 10.1126/science.aah6752. Epub 2017 Jan 12.
5
A balance between elongation and trimming regulates telomere stability in stem cells.延伸与修剪之间的平衡调节干细胞中的端粒稳定性。
Nat Struct Mol Biol. 2017 Jan;24(1):30-39. doi: 10.1038/nsmb.3335. Epub 2016 Dec 5.
6
HOT1 is a mammalian direct telomere repeat-binding protein contributing to telomerase recruitment.HOT1 是一种哺乳动物直接结合端粒重复序列的蛋白,有助于端粒酶的招募。
EMBO J. 2013 Jun 12;32(12):1681-701. doi: 10.1038/emboj.2013.105. Epub 2013 May 17.
7
BTB-ZF factors recruit the E3 ligase cullin 3 to regulate lymphoid effector programs.BTB-ZF 因子招募 E3 连接酶 cullin3 来调节淋巴样效应器程序。
Nature. 2012 Nov 22;491(7425):618-21. doi: 10.1038/nature11548. Epub 2012 Oct 21.
8
Carbon-oxygen hydrogen bonding in biological structure and function.碳-氧-氢键在生物结构和功能中的作用。
J Biol Chem. 2012 Dec 7;287(50):41576-82. doi: 10.1074/jbc.R112.418574. Epub 2012 Oct 9.
9
The role of telomere trimming in normal telomere length dynamics.端粒修剪在正常端粒长度动态变化中的作用。
Cell Cycle. 2012 Apr 1;11(7):1309-15. doi: 10.4161/cc.19632.
10
Normal mammalian cells negatively regulate telomere length by telomere trimming.正常的哺乳动物细胞通过端粒修剪来负调控端粒长度。
Hum Mol Genet. 2011 Dec 1;20(23):4684-92. doi: 10.1093/hmg/ddr402. Epub 2011 Sep 8.

The 11th C2H2 zinc finger and an adjacent C-terminal arm are responsible for TZAP recognition of telomeric DNA.

作者信息

Zhao Yaqing, Zhang Guang, He Chao, Mei Yide, Shi Yunyu, Li Fudong

机构信息

Hefei National Laboratory for Physical Sciences at Microscale and School of Life Sciences, University of Science and Technology of China, Hefei, Anhui 230026, China.

Anhui Key Laboratory of Modern Biomanufacturing and School of Life Sciences, Anhui University, Hefei, Anhui 230601, China.

出版信息

Cell Res. 2018 Jan;28(1):130-134. doi: 10.1038/cr.2017.141. Epub 2017 Nov 14.

DOI:10.1038/cr.2017.141
PMID:29134956
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5752842/
Abstract
摘要