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The 11th C2H2 zinc finger and an adjacent C-terminal arm are responsible for TZAP recognition of telomeric DNA.

作者信息

Zhao Yaqing, Zhang Guang, He Chao, Mei Yide, Shi Yunyu, Li Fudong

机构信息

Hefei National Laboratory for Physical Sciences at Microscale and School of Life Sciences, University of Science and Technology of China, Hefei, Anhui 230026, China.

Anhui Key Laboratory of Modern Biomanufacturing and School of Life Sciences, Anhui University, Hefei, Anhui 230601, China.

出版信息

Cell Res. 2018 Jan;28(1):130-134. doi: 10.1038/cr.2017.141. Epub 2017 Nov 14.

Abstract
摘要

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本文引用的文献

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ZBTB48 is both a vertebrate telomere-binding protein and a transcriptional activator.
EMBO Rep. 2017 Jun;18(6):929-946. doi: 10.15252/embr.201744095. Epub 2017 May 12.
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TZAP-ing telomeres down to size.
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TZAP or not to zap telomeres.
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BTB-ZF factors recruit the E3 ligase cullin 3 to regulate lymphoid effector programs.
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Normal mammalian cells negatively regulate telomere length by telomere trimming.
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