Gata Vlad, Florin Laurentiu Ignat
Faculty of Medicine, "Iuliu Hatieganu" University of Medicine and Pharmacy, Cluj-Napoca, Romania.
J BUON. 2017 Sep-Oct;22(5):1092-1096.
Ovarian cancer (OC) is the leading cause of death in gynecological malignancies in western countries. Chemoresistance represents a major issue and a better understanding of the interactions that take place within the tumor microenvironment is needed, such as the connection between inflammation and cancer. Toll like receptors (TLRs) are part of the basic mechanisms that are involved in the activation of the innate immune system, with extensive activation of various transcription factors, that subsequently lead to an adaptive immune response, making them key players that modulate the inflammatory response and tumor dynamics. In the same time, activation of TLRs on OC cells can lead to a different type of response that favors an aggressive phenotype and tumor progression. Herein, we review the recent evidence towards the role of TLRs in OC and the therapeutic strategies that have already commenced.
卵巢癌（OC）是西方国家妇科恶性肿瘤死亡的主要原因。化疗耐药是一个主要问题，需要更好地了解肿瘤微环境中发生的相互作用，例如炎症与癌症之间的联系。Toll样受体（TLRs）是参与先天免疫系统激活的基本机制的一部分，可广泛激活各种转录因子，随后导致适应性免疫反应，使其成为调节炎症反应和肿瘤动态的关键因素。同时，OC细胞上TLRs的激活可导致不同类型的反应，有利于侵袭性表型和肿瘤进展。在此，我们综述了TLRs在OC中的作用的最新证据以及已经开始的治疗策略。
