Markoulli Maria, Duong Tran Bao, Lin Margaret, Papas Eric
a School of Optometry & Vision Science, University of New South Wales , Sydney , Australia.
Curr Eye Res. 2018 Feb;43(2):155-162. doi: 10.1080/02713683.2017.1393092. Epub 2017 Nov 14.
To compare non-invasive break-up time (NIBUT) when measured with the Tearscope-Plus™ and the Oculus® Keratograph 5M, and to compare lipid layer thicknesses (LLT) when measured with the Tearscope-Plus™ and the LipiView®. This study also set out to establish the repeatability of these methods.
The following measurements were taken from both eyes of 24 participants on two occasions: non-invasive keratograph break-up time using the Oculus® (NIKBUT-1 and NIKBUT-average), NIBUT using the Tearscope-Plus™, and LLT using the LipiView® (minimum, maximum, and average) and Tearscope-Plus™. The Tearscope-Plus™ grades were converted to nanometers.
There were no significant differences between eyes (Tearscope-Plus™ NIBUT: p = 0.52; NIKBUT-1: p = 0.052; NIKBUT-average: p = 0.73; Tearscope-Plus™ LLT: p = 0.13; LipiView® average, maximum, or minimum: p = 0.68, 0.39 and 0.50, respectively) or days (Tearscope-Plus™ NIBUT: p = 0.32; NIKBUT-1: p = 0.65; NIKBUT-average: p = 0.54; Tearscope-Plus™ LLT: p = 0.26; LipiView® average, maximum, or minimum: p = 0.20, 0.09, and 0.10, respectively). LLT was significantly greater with the Tearscope-Plus™ (80.4 ± 34.0 nm) compared with the LipiView® average (56.3 ± 16.1 nm, p = 0.007), minimum (50.1 ± 15.8 nm, p < 0.001) but not maximum (67.2 ± 19.6 nm, p = 0.55). NIBUT was significantly greater with the Tearscope-Plus™ (15.9 ± 10.7 seconds) compared to the NIKBUT-1 (8.2 ± 3.5 seconds, p = 0.006) but not NIKBUT-average (10.9 ± 3.9 seconds, p = 0.08).
The Tearscope-Plus™ is not interchangeable with either the Oculus® K5M measurement of tear stability (NIKBUT-1) or the LipiView® maximum and minimum lipid thickness.
比较使用Tearscope-Plus™和Oculus® Keratograph 5M测量的非侵入性泪膜破裂时间（NIBUT），以及使用Tearscope-Plus™和LipiView®测量的脂质层厚度（LLT）。本研究还旨在确定这些方法的可重复性。
对24名参与者的双眼进行两次以下测量：使用Oculus®测量的非侵入性角膜地形图破裂时间（NIKBUT-1和NIKBUT平均值）、使用Tearscope-Plus™测量的NIBUT，以及使用LipiView®（最小值、最大值和平均值）和Tearscope-Plus™测量的LLT。将Tearscope-Plus™的等级转换为纳米。
双眼之间（Tearscope-Plus™ NIBUT：p = 0.52；NIKBUT-1：p = 0.052；NIKBUT平均值：p = 0.73；Tearscope-Plus™ LLT：p = 0.13；LipiView®平均值、最大值或最小值：分别为p = 0.68、0.39和0.50）或不同天数之间（Tearscope-Plus™ NIBUT：p = 0.32；NIKBUT-1：p = 0.65；NIKBUT平均值：p = 0.54；Tearscope-Plus™ LLT：p = 0.26；LipiView®平均值、最大值或最小值：分别为p = 0.20、0.09和0.10）均无显著差异。与LipiView®平均值（56.3±16.1纳米，p = 0.007）、最小值（50.1±15.8纳米，p < 0.001）相比，Tearscope-Plus™测量的LLT显著更大，但与最大值（67.2±19.6纳米，p = 0.55）相比无显著差异。与NIKBUT-1（8.2±3.5秒，p = 0.006）相比，Tearscope-Plus™测量的NIBUT显著更长，但与NIKBUT平均值（10.9±3.9秒，p = 0.08）相比无显著差异。
Tearscope-Plus™与Oculus® K5M测量的泪膜稳定性（NIKBUT-1）或LipiView®的脂质层最大和最小厚度均不可互换。
