National Engineering Research Center for Biomaterials, Sichuan University, 29 Wangjiang Road, Chengdu 610064, China.
College of Materials Science & Engineering, Nanjing Tech University, 30 South Puzhu Road, Nanjing 211816, China.
Nanomedicine (Lond). 2017 Dec;12(24):2763-2783. doi: 10.2217/nnm-2017-0265. Epub 2017 Nov 14.
To build up a remote triggering drug delivery system with hyperthermia-responsive ammonium bicarbonate salt and investigate its effects on tumor therapy.
MATERIALS & METHODS: This hybrid nanocapsule system was prepared by a different strategy, doxorubicin (DOX) was encapsulated in the heparin shell first and then ammonium bicarbonate was diffused into the nanocapsules to generate DOX-bicarbonate salt, its characterizations and effects on tumor therapy were investigated.
Upon exposure to mild external thermal treatment (42°C), DOX-bicarbonate salt began to decompose with the recovery of DOX fluorescence, carbon dioxide generation and rapid DOX release out of the nanocapsules, exhibiting great abilities to accumulate at tumor site rapidly and inhibit tumor cell growth.
These hybrid nanocapsules demonstrate great potential in clinical applications triggering by external thermal treatment.
构建一种具有热响应性碳酸氢铵盐的远程触发药物递送系统，并研究其在肿瘤治疗中的作用。
该混合纳米胶囊系统采用不同的策略制备，阿霉素（DOX）首先被包裹在肝素壳中，然后将碳酸氢铵扩散到纳米胶囊中生成 DOX-碳酸氢盐，对其性质及其对肿瘤治疗的影响进行了研究。
在温和的外部热疗（42°C）下，DOX-碳酸氢盐开始分解，同时恢复 DOX 的荧光，生成二氧化碳，并迅速将 DOX 从纳米胶囊中释放出来，表现出快速聚集在肿瘤部位和抑制肿瘤细胞生长的强大能力。
这些混合纳米胶囊在外热疗触发下具有很大的临床应用潜力。
