Department of Dermatology and Allergy, Herlev and Gentofte University Hospital, University of Copenhagen, Kildegaardsvej 28, DK-2900 Hellerup, Denmark.
Acta Derm Venereol. 2018 Mar 13;98(3):361-365. doi: 10.2340/00015555-2842.
Recent findings indicate that patients with systemic sclerosis have an increased risk of cardiovascular disease. To determine whether patients with systemic sclerosis or localized scleroderma are at increased risk of cardiovascular disease, a cohort study of the entire Danish population aged ≥ 18 and ≤ 100 years was conducted, followed from 1997 to 2011 by individual-level linkage of nationwide registries. Multivariable adjusted Cox regression models were used to estimate the hazard ratios (HRs) for a composite cardiovascular disease endpoint. A total of 697 patients with localized scleroderma and 1,962 patients with systemic sclerosis were identified and compared with 5,428,380 people in the reference population. In systemic sclerosis, the adjusted HR was 2.22 (95% confidence interval 1.99-2.48). No association was seen between patients with localized scleroderma and cardiovascular disease. In conclusion, systemic sclerosis is a significant cardiovascular disease risk factor, while patients with localized scleroderma are not at increased risk of cardiovascular disease.
最近的研究结果表明，系统性硬化症患者患心血管疾病的风险增加。为了确定系统性硬化症或局限性硬皮病患者是否存在心血管疾病风险增加的情况，对整个丹麦≥ 18 岁且≤ 100 岁的人群进行了队列研究，并在 1997 年至 2011 年期间通过全国性登记册的个体水平链接进行随访。使用多变量调整的 Cox 回归模型来估计复合心血管疾病终点的风险比（HR）。共确定了 697 例局限性硬皮病患者和 1962 例系统性硬化症患者，并与参考人群中的 5428380 人进行了比较。在系统性硬化症中，调整后的 HR 为 2.22（95%置信区间 1.99-2.48）。局限性硬皮病患者与心血管疾病之间没有关联。总之，系统性硬化症是心血管疾病的重要危险因素，而局限性硬皮病患者患心血管疾病的风险并未增加。
