作为螺旋模板的后功能化肽折叠体的合理设计与合成
Rational Design and Synthesis of Post-Functionalizable Peptide Foldamers as Helical Templates.
作者信息
Misawa Takashi, Kanda Yasunari, Demizu Yosuke
机构信息
Division of Organic Chemistry and ‡Division of Pharmacology, National Institute of Health Sciences , Tokyo 158-8501, Japan.
出版信息
Bioconjug Chem. 2017 Dec 20;28(12):3029-3035. doi: 10.1021/acs.bioconjchem.7b00621. Epub 2017 Nov 29.
Abstract
In this study, we developed post-functionalizable helical peptides composed of Leu, Aib, and Azl residues. We show that the synthesized peptides 1 and 2 form helical structures, and may be modified using specific side chain or several functional groups by the click reaction without influencing their secondary structures.
摘要
在本研究中，我们开发了由亮氨酸（Leu）、α-氨基异丁酸（Aib）和叠氮赖氨酸（Azl）残基组成的可后功能化螺旋肽。我们表明，合成的肽1和肽2形成螺旋结构，并且可以通过点击反应使用特定侧链或几个官能团进行修饰，而不会影响其二级结构。
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