两面性的 mSWI/SNF 亚基：ARID1A 在肝脏中的抑瘤和致癌双重作用。
A Two-Faced mSWI/SNF Subunit: Dual Roles for ARID1A in Tumor Suppression and Oncogenicity in the Liver.
机构信息
Chemical Biology Program, Harvard University, Cambridge, MA 02138, USA; Department of Pediatric Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA 02215, USA.
Chemical Biology Program, Harvard University, Cambridge, MA 02138, USA; Department of Pediatric Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA 02215, USA.
出版信息
Cancer Cell. 2017 Nov 13;32(5):542-543. doi: 10.1016/j.ccell.2017.10.014.
In this issue of Cancer Cell, Sun et al. describe context-dependent oncogenic and tumor-suppressive functions for the mammalian SWI/SNF (BAF) complex subunit ARID1A in the development and progression of hepatocellular carcinoma (HCC).
在本期《癌细胞》中，孙等人描述了哺乳动物 SWI/SNF（BAF）复合物亚基 ARID1A 在肝细胞癌（HCC）发生和发展过程中具有依赖于上下文的致癌和肿瘤抑制功能。
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