早期的 GalNAc O-糖基化：推动肿瘤边界。
Early GalNAc O-Glycosylation: Pushing the Tumor Boundaries.
机构信息
i3S - Institute for Research and Innovation in Health, University of Porto, 4200-135 Porto, Portugal; IPATIMUP - Institute of Molecular Pathology and Immunology, University of Porto, 4200-465 Porto, Portugal.
i3S - Institute for Research and Innovation in Health, University of Porto, 4200-135 Porto, Portugal; IPATIMUP - Institute of Molecular Pathology and Immunology, University of Porto, 4200-465 Porto, Portugal; Instituto de Ciências Biomédicas Abel Salazar (ICBAS), University of Porto, 4050-313 Porto, Portugal; Faculty of Medicine, University of Porto, 4200-319 Porto, Portugal.
出版信息
Cancer Cell. 2017 Nov 13;32(5):544-545. doi: 10.1016/j.ccell.2017.10.010.
Glycosylation alterations are frequently observed in cancer cells and shape tumor progression. In this issue of Cancer Cell, Nguyen et al. show that GALNT1 relocation from Golgi to endoplasmic reticulum drives liver tumor growth and invasion, due to enhanced glycosylation and consequential activation of the extracellular matrix-degrading metalloproteinase MMP14.
糖基化修饰在癌细胞中经常被观察到，并且塑造了肿瘤的进展。在本期《癌细胞》杂志中，Nguyen 等人表明，GALNT1 从高尔基体到内质网的重新定位导致了肝脏肿瘤的生长和侵袭，这是由于糖基化增强以及随后细胞外基质降解金属蛋白酶 MMP14 的激活所致。
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