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[甲状腺手术中不同肌电图阈值下喉返神经损伤后的功能恢复]

[Functional recovery after recurrent laryngeal nerve injury on different electromyography thresholds during thyroid surgery].

作者信息

Liu X L, Li C L, Zhao Y S, Sun H

机构信息

Department of Thyroid Surgery, China-Japan Union Hospital Affiliated to Jilin University, Jilin Provincial Key Laboratory of Surgical Translational Medicine, Changchun 130033, China.

出版信息

Zhonghua Wai Ke Za Zhi. 2017 Nov 1;55(11):853-856. doi: 10.3760/cma.j.issn.0529-5815.2017.11.007.

Abstract

To discuss the functional recovery after recurrent laryngeal nerve injury (RLNI) on different electromyography thresholds during thyroid surgery. The prospective experimentally were induced in 12 acute recurrent laryngeal traction animals (porcine) from December 2014 to December 2015, the amplitude and latency of electromyography, even time course during RLNI and recovery of 24 recurrent laryngeal nerves(RLN) were continuous intraoperative neuromonitoring(IONM), including 12 RLN releasing traction after 50% amplitude decrease (AD) and other 12 RLN after 70% AD. The IONM data and postoperative laryngoscopy result of 1 119 thyroid cancer patients, involved 237 male and 882 female, aged 45.2 years in average, who underwent thyroidectomy in Department of Thyroid Surgery, China-Japan Union Hospital Affiliated to Jilin University from July to December in 2016 were analyzed retrospectively. The porcine model of traction lesion showed that the time of 50% AD was (59±4) s, latency increase (LI) was (8± 4)%, was recovered in 10 minutes; the time of 70% AD was (75±6)s, LI was (11±5)% , was recovered (43±23)% of baseline even during 20 minutes. Among the IONM of 1 632 recurrent laryngeal nerves in clinic, the mechanism of 64 RLNI is clear, including traction injury accounted for 62.5% (40/64), thermal injury was 12.5% (8/64), compression injury was 23.4% (15/64), clamp injury was 1.6% (1/64). When 50%≤AD <70% (8.8%), the rate of abnormal vocal fold movement (AVCM) was 8.8% (6/68), while AD≥70% (37.2%), the rate of AVCM was 37.2% (19/51), but LOS was 5/13. Releasing the injury before AD≥50% in surgery, is a more effective indicator to avoid postoperative AVCM and promote nerve function recovery.

摘要

探讨甲状腺手术中不同肌电图阈值下喉返神经损伤(RLNI)后的功能恢复情况。2014年12月至2015年12月,对12只急性喉返神经牵拉动物(猪)进行前瞻性实验,术中连续进行神经监测(IONM),记录24条喉返神经(RLN)在喉返神经损伤(RLNI)及恢复过程中的肌电图振幅、潜伏期及时间进程,包括12条在振幅下降50%(AD)后解除牵拉的RLN和另外12条在振幅下降70%后解除牵拉的RLN。回顾性分析2016年7月至12月在吉林大学中日联谊医院甲状腺外科行甲状腺切除术的1例19例甲状腺癌患者的IONM数据及术后喉镜检查结果,其中男性237例,女性882例,平均年龄45.2岁。猪牵拉损伤模型显示,50%AD的时间为(59±4)s,潜伏期增加(LI)为(8±4)%,10分钟内恢复;70%AD的时间为(75±6)s,LI为(11±5)%,即使在20分钟内也仅恢复至基线的(43±23)%。在临床1632条喉返神经的IONM中,64条RLNI的机制明确,其中牵拉损伤占62.5%(40/64),热损伤占12.5%(8/64),压迫损伤占23.4%(15/64),钳夹损伤占1.6%(1/64)。当50%≤AD<70%(8.8%)时,声带异常运动(AVCM)发生率为8.8%(6/68),而AD≥70%(37.2%)时,AVCM发生率为37.2%(19/51),但住院时间为5/13。术中在AD≥50%前解除损伤,是避免术后AVCM及促进神经功能恢复的更有效指标。

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