Luo J S, Lyu Y B, Yin Z X, Shi W H, Zhang J, Su L Q, Fang J L, Shi X M
Division of Non-Communicable Disease Control and Community Health, Chinese Center for Disease Control and Prevention, Beijing 102206, China.
Zhonghua Yu Fang Yi Xue Za Zhi. 2017 Nov 6;51(11):1012-1018. doi: 10.3760/cma.j.issn.0253-9624.2017.11.011.
To explore the association between biomarkers and activities of daily living (ADL) in the elderly over 65 years old from longevity areas in China. A total of 2 439 people from 8 longevity areas were included in our baseline survey in 2012. Using questionnaires, body measurements, and blood biochemical examinations, information on demographics characteristic, life style, ADL, blood pressure and biomarkers were collected. Based on these six items of ADL (bathing, dressing, indoor activities, toileting, eating, bowel and bladder control), we constructed a dichotomous indicator for ADL. A respondent was defined as ADL disabled if any difficulty in one or more of the above six activities was reported. Information were collected in the follow-up in 2014 using the same questionnaires and examinations. We excluded information on the elderly who lacked ADL or biomarkers test results or with ADL disability at baseline study. Finally 938 elderly people over 65 years old were included in this analysis. Multivariate logistic regression model was used to analyze the influence factors of ADL disability. During the 2-year follow-up, 100 (10.7%) participants developed into ADL disability, with a rate at 10.7%. Multivariate logistic regression analysis indicated that each year increase in age or each 1 mmHg (1 mmHg=0.133 kPa) increase in systolic blood pressure (SBP) would cause the risk of ADL disability to increase 9% or 1%, whose (95%) were separately 1.09 (1.06-1.12), 1.01 (1.00-1.02). Han nationality or cognitive impairment increased the risk of ADL disability, whose (95%) values were separately 4.90 (1.13-21.24), 2.47 (1.44-4.25), while increased lymphocyte count (>1.60×10(9)/L), being married, or participating in recreational activities decreased the risk of ADL disability, whose (95%) values were separately 0.51 (0.31-0.82), 0.52 (0.28-0.96), 0.43 (0.23-0.80). In the elderly elevated lymphocyte count was associated with lower risk of ADL disability. In addition, incresed age, increased SBP, unmarried, Han nationality or cognitive impairment were associated with the increasing risk of ADL disability in older people, while participating in recreational activities would reduce the risk.
为探究中国长寿地区65岁以上老年人生物标志物与日常生活活动（ADL）之间的关联。2012年，我们对来自8个长寿地区的2439人进行了基线调查。通过问卷调查、身体测量和血液生化检查，收集了人口统计学特征、生活方式、ADL、血压和生物标志物等信息。基于ADL的这六个项目（洗澡、穿衣、室内活动、如厕、进食、排便和膀胱控制），我们构建了一个ADL的二分指标。如果报告在上述六项活动中的一项或多项存在困难，则将受访者定义为ADL残疾。2014年随访时使用相同的问卷和检查收集信息。我们排除了在基线研究中缺乏ADL或生物标志物检测结果或有ADL残疾的老年人的信息。最终，938名65岁以上的老年人被纳入本分析。采用多因素logistic回归模型分析ADL残疾的影响因素。在2年的随访期间，100名（10.7%）参与者发展为ADL残疾，发生率为10.7%。多因素logistic回归分析表明，年龄每增加1岁或收缩压（SBP）每升高1 mmHg（1 mmHg = 0.133 kPa），ADL残疾风险将分别增加9%或1%，其（95%）置信区间分别为1.09（1.06 - 1.12）、1.01（1.00 - 1.02）。汉族或认知障碍会增加ADL残疾风险，其（95%）置信区间分别为4.90（1.13 - 21.24）、2.47（1.44 - 4.25），而淋巴细胞计数增加（>1.60×10⁹/L）、已婚或参加娱乐活动会降低ADL残疾风险，其（95%）置信区间分别为0.51（0.31 - 0.82）、0.52（0.28 - 0.96）、0.43（0.23 - 0.80）。在老年人中，淋巴细胞计数升高与较低的ADL残疾风险相关。此外，年龄增加、SBP升高、未婚、汉族或认知障碍与老年人ADL残疾风险增加相关，而参加娱乐活动会降低风险。
