DropSens, S.L., Ed. CEEI, Parque Tecnológico de Asturias, 33428 Llanera, Asturias, Spain.
DropSens, S.L., Ed. CEEI, Parque Tecnológico de Asturias, 33428 Llanera, Asturias, Spain.
Talanta. 2018 Feb 1;178:85-88. doi: 10.1016/j.talanta.2017.09.004. Epub 2017 Sep 6.
Naratriptan, active pharmaceutical ingredient with antimigraine activity was electrochemically detected in untreated screen-printed carbon electrodes (SPCEs). Cyclic voltammetry and differential pulse voltammetry were used to carry out quantitative analysis of this molecule (in a Britton-Robinson buffer solution at pH 3.0) through its irreversible oxidation (diffusion controlled) at a potential of +0.75V (vs. Ag pseudoreference electrode). Naratriptan oxidation product is an indole based dimer with a yellowish colour (maximum absorption at 320nm) so UV-VIS spectroelectrochemistry technique was used for the very first time as an in situ characterization and quantification technique for this molecule. A reflection configuration approach allowed its measurement over the untreated carbon based electrode. Finally, time resolved Raman Spectroelectrochemistry is used as a powerful technique to carry out qualitative and quantitative analysis of Naratriptan. Electrochemically treated silver screen-printed electrodes are shown as easy to use and cost-effective SERS substrates for the analysis of Naratriptan.
那拉曲普坦是一种具有抗偏头痛活性的药物活性成分，在未经处理的丝网印刷碳电极（SPCE）中可被电化学检测到。通过循环伏安法和差分脉冲伏安法，在 Britton-Robinson 缓冲溶液（pH3.0）中，对该分子进行定量分析，其在+0.75V（相对于 Ag 伪参比电极）的位置发生不可逆氧化（扩散控制）。那拉曲普坦氧化产物是一种基于吲哚的二聚体，具有淡黄色（在 320nm 处有最大吸收），因此，首次将紫外-可见光谱电化学技术用作该分子的原位表征和定量技术。反射配置方法允许在未经处理的碳基电极上进行测量。最后，时间分辨的拉曼光谱电化学被用作一种强大的技术，对那拉曲普坦进行定性和定量分析。电化学处理的银丝网印刷电极被证明是一种易于使用且具有成本效益的 SERS 基底，可用于分析那拉曲普坦。
