CXCL6 通过下调 miR-515-5p 促进非小细胞肺癌细胞的存活和转移。
CXCL6 promotes non-small cell lung cancer cell survival and metastasis via down-regulation of miR-515-5p.
机构信息
Department of Respiratory, First Affiliated Hospital of Soochow University, Suzhou, China; Department of Respiratory, Affiliated Hospital of Nantong University, Nantong, China.
Department of Respiratory, Affiliated Hospital of Nantong University, Nantong, China.
出版信息
Biomed Pharmacother. 2018 Jan;97:1182-1188. doi: 10.1016/j.biopha.2017.11.004. Epub 2017 Nov 11.
Chemokine plays an important role in lung cancer and CXCL6 is one of chemokine, however, its effect on miRNAs profile and its roles in non-small cell lung cancer cell (NSCLC) is not elucidated. This study is purposed to explore the influence of CXCL6 on miRNA expression profile and found that CXCL6 could reduce the expression of miR-515-5p in NSCLC cells. MiR-515-5p in NSCLC cells could inhibit NSCLC survival and metastasis. MiR-515-5p acted as a tumor suppressor by targeting CXCL6 in NSCLC cells. These data highlighted a novel molecular interaction between miR-515-5p and CXCL6. MiR-515-5p may constitute a potential therapy target for NSCLC.
趋化因子在肺癌中发挥着重要作用，CXCL6 是趋化因子之一，但其对 miRNA 谱的影响及其在非小细胞肺癌细胞（NSCLC）中的作用尚不清楚。本研究旨在探讨 CXCL6 对 miRNA 表达谱的影响，发现 CXCL6 可降低 NSCLC 细胞中 miR-515-5p 的表达。NSCLC 细胞中的 miR-515-5p 可抑制 NSCLC 的存活和转移。miR-515-5p 通过在 NSCLC 细胞中靶向 CXCL6 发挥肿瘤抑制作用。这些数据突出了 miR-515-5p 和 CXCL6 之间新的分子相互作用。miR-515-5p 可能成为 NSCLC 的潜在治疗靶点。
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