Zhou Chenjia, Gao Ying, Ding Peilun, Wu Tao, Ji Guang
Institute of Digestive Disease, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, 200032, Shanghai, China.
Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, 201203, Shanghai, China.
Cell Death Discov. 2023 Jul 1;9(1):212. doi: 10.1038/s41420-023-01524-9.
Chemokines are a large family mediating a lot of biological behaviors including chemotaxis, tumor growth, angiogenesis and so on. As one member of this family, CXC subfamily possesses the same ability. CXC chemokines can recruit and migrate different categories of immune cells, regulate tumor's pathological behaviors like proliferation, invasion and metastasis, activate angiogenesis, etc. Due to these characteristics, CXCL subfamily is extensively and closely associated with tumors and inflammatory diseases. As studies are becoming more and more intensive, CXCLs' concrete roles are better described, and CXCLs' therapeutic applications including biomarkers and targets are also deeply explained. In this review, the role of CXCL family members in various diseases is summarized.
趋化因子是一个大家族，介导许多生物学行为，包括趋化作用、肿瘤生长、血管生成等。作为该家族的一员，CXC亚家族具有相同的能力。CXC趋化因子可以募集和迁移不同类型的免疫细胞，调节肿瘤的增殖、侵袭和转移等病理行为，激活血管生成等。由于这些特性，CXCL亚家族与肿瘤和炎症性疾病广泛且密切相关。随着研究越来越深入，CXCLs的具体作用得到了更好的描述，CXCLs的治疗应用，包括生物标志物和靶点，也得到了深入的解释。在这篇综述中，总结了CXCL家族成员在各种疾病中的作用。
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