Liu Yuan, Jia Yanfei, Cao Yuju, Zhao Yan, Du Jieli, An Feimeng, Qi Yuxin, Feng Xue, Jin Tianbo, Shi Jianping, Wang Jianzhong
Inner Mongolia Medical University, Hohhot, Inner Mongolia, China.
Department of Orthopedics and Traumatology, The Second Affiliated Hospital of Inner Mongolia University, Hohhot, Inner Mongolia, China.
Oncotarget. 2017 Aug 24;8(47):82835-82841. doi: 10.18632/oncotarget.20463. eCollection 2017 Oct 10.
Non-traumatic osteonecrosis of femoral head (ONFH) is an orthopedic refractory disease with escalating morbidity in Chinese Han population. In our case-control study, we examined eight previously identified single-nucleotide polymorphisms (SNPs) in 585 non-traumatic ONFH patients and 507 healthy individuals from northern China to determine whether these SNPs associated with the risk of developing non-traumatic ONFH. Genetic model and haplotype analyses were used to evaluate the association between SNPs and non-traumatic ONFH. rs2274755 (OR, 0.740; 95% CI, 0.578-0.949; p = 0.017) was associated with a reduced risk of non-traumatic ONFH. After adjusting for age and gender, the logistic regression results showed that rs2274755 associated with a lower risk of non-traumatic ONFH in the dominant (OR=0.71, 95% CI: 0.54-0.94, p=0.016), overdominant (OR=0.73, 95% CI: 0.55-0.96, p=0.026) and log-additive (OR=0.74740; 95% CI, 0.578-0.949; p=0.017) models. In addition, the "TGC" haplotype of rs2274755 was associated with a 0.79-fold decrease in risk while the "CTC" haplotype associated with a 0.65-fold decrease risk of the non-traumatic ONFH. These results provide evidence that the SNP at the rs2274755 locus is associated with a decreased risk of non-traumatic ONFH in a Chinese Han population.
非创伤性股骨头坏死（ONFH）是一种骨科难治性疾病，在中国汉族人群中的发病率呈上升趋势。在我们的病例对照研究中，我们检测了来自中国北方的585例非创伤性ONFH患者和507名健康个体中8个先前鉴定出的单核苷酸多态性（SNP），以确定这些SNP是否与非创伤性ONFH的发病风险相关。采用遗传模型和单倍型分析来评估SNP与非创伤性ONFH之间的关联。rs2274755（比值比，0.740；95%置信区间，0.578 - 0.949；p = 0.017）与非创伤性ONFH风险降低相关。在调整年龄和性别后，逻辑回归结果显示，rs2274755在显性（比值比 = 0.71，95%置信区间：0.54 - 0.94，p = 0.016）、超显性（比值比 = 0.73，95%置信区间：0.55 - 0.96，p = 0.026）和对数相加（比值比 = 0.74740；95%置信区间，0.578 - 0.949；p = 0.017）模型中与非创伤性ONFH风险降低相关。此外，rs227舍罕王4755的“TGC”单倍型与风险降低0.79倍相关，而“CTC”单倍型与非创伤性ONFH风险降低0.65倍相关。这些结果提供了证据，表明rs2274755位点的SNP与中国汉族人群中非创伤性ONFH风险降低相关。
