Eden Robert D, Evans Mark I, Evans Shara M, Schifrin Barry S
1 Fetal Medicine Foundation of America, New York, NY, USA.
2 Comprehensive Genetics, PLLC, New York, NY, USA.
Reprod Sci. 2018 Apr;25(4):487-497. doi: 10.1177/1933719117737849. Epub 2017 Nov 14.
The near-ubiquitous use of electronic fetal monitoring has failed to lower the rates of both cerebral palsy and emergency operative deliveries (EODs). Its performance metrics have low sensitivity, specificity, and predictive values for both. There are many EODs, but the vast majority have normal outcomes. The EODs, however, cause serious disruption in the delivery suite routine with increased complications, anxiety, and concern for all.
We developed the fetal reserve index (FRI) as multicomponent algorithm including 4 FHR components (analyzed individually), uterine activity, and maternal, obstetrical, and fetal risk factors to assess risk of cerebral palsy and EOD. Scores were categorized into green, yellow, and red zones. Here, we studied 300 patients by the FRI, all of whom had normal neonatal outcomes. We attempted to distinguish the clinical course of those cases which required an EOD versus controls which did not.
51 cases with EOD had FRIs much lower than 249 non-EOD cases. The red zone was reached more frequently ( P < .001) and lasted longer (1.06 vs 0.05 hours; P < .001). Reaching the red zone had a sensitivity of 92% for EOD, with a positive predictive value of 64% and a false positive rate of 10.4%.
Our data suggest the FRI can significantly lower the incidence of EODs by identifying the opportunity for intrauterine resuscitation. Our approach can reduce the disruptive effects of EODs and their concomitant increased risks of complications. The FRI may provide a metric that can refine labor management to reduce CP and EODs.
电子胎儿监护几乎无处不在的应用未能降低脑瘫和急诊手术分娩(EOD)的发生率。其性能指标对两者的敏感性、特异性和预测价值均较低。急诊手术分娩的情况很多,但绝大多数结局正常。然而,急诊手术分娩会严重扰乱产房常规,增加并发症、焦虑情绪,并引发各方的担忧。
我们开发了胎儿储备指数(FRI),这是一种多组分算法,包括4个胎儿心率组分(单独分析)、子宫活动以及母体、产科和胎儿风险因素,以评估脑瘫和急诊手术分娩的风险。分数分为绿色、黄色和红色区域。在此,我们通过胎儿储备指数研究了300例患者,所有患者的新生儿结局均正常。我们试图区分那些需要急诊手术分娩的病例与不需要急诊手术分娩的对照病例的临床过程。
51例急诊手术分娩病例的胎儿储备指数远低于249例非急诊手术分娩病例。红色区域的出现频率更高(P < .001),且持续时间更长(1.06小时对0.05小时;P < .001)。达到红色区域对急诊手术分娩的敏感性为92%,阳性预测值为64%,假阳性率为10.4%。
我们的数据表明,胎儿储备指数可通过识别宫内复苏的时机显著降低急诊手术分娩的发生率。我们的方法可以减少急诊手术分娩的干扰作用及其随之增加的并发症风险。胎儿储备指数可能提供一种可优化产程管理以降低脑瘫和急诊手术分娩发生率的指标。