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使用安装在万向架上的直线加速器进行容积调强弧形治疗时动态肿瘤跟踪的几何和剂量学精度。

Geometric and dosimetric accuracy of dynamic tumor tracking during volumetric-modulated arc therapy using a gimbal mounted linac.

机构信息

Department of Radiation Oncology and Image-applied Therapy, Graduate School of Medicine, Kyoto University, Japan; Department of Radiation Oncology, Wakayama Red Cross Hospital, Japan.

Department of Radiation Oncology and Image-applied Therapy, Graduate School of Medicine, Kyoto University, Japan.

出版信息

Radiother Oncol. 2018 Oct;129(1):166-172. doi: 10.1016/j.radonc.2017.10.034. Epub 2017 Nov 11.

Abstract

PURPOSE

The aim was to examine the feasibility of a dynamic tumor-tracking volumetric modulated arc therapy (DTT-VMAT) technique using a gimbal-mounted linac and assess its positional, mechanical and dosimetric accuracy.

MATERIALS AND METHODS

DTT-VMAT was performed using a surrogated signal-based technique. The positional tracking accuracy was evaluated as the difference between the predicted and detected target positions for various wave patterns. Mechanical accuracy measurements included gantry, multileaf collimator (MLC) and gimbal positions. The differences between the command and the measured positions were evaluated for various wave patterns. Dosimetric verification was performed using Gafchromic EBT3 films in the benchmark phantom and two clinical cases.

RESULTS

The root mean square error (RMSE) of the positional accuracy was within 0.31 mm. The RMSE of mechanical accuracy was within 0.14° for the gantry, 0.11 ± 0.02 mm for the MLC and 0.13 mm for the gimbal positions. The passing rate of the 3%/3 mm gamma index was greater than 83.3% and 91.2% for the benchmark phantom and two clinical cases, respectively.

CONCLUSIONS

The positional, mechanical and dosimetric accuracy of DTT-VMAT were evaluated. DTT-VMAT with a gimbal-mounted linac had sufficient accuracy and presents a new strategy for treatment of several tumors with respiratory motion.

摘要

目的

旨在研究基于万向节安装直线加速器的动态肿瘤追踪容积调强弧形治疗(DTT-VMAT)技术的可行性,并评估其位置、机械和剂量学准确性。

材料与方法

采用基于替代信号的技术进行 DTT-VMAT。评估了各种波形下目标位置预测值与检测值之间的差异,以确定位置跟踪准确性。机械精度测量包括旋转机架、多叶准直器(MLC)和万向节位置。评估了各种波形下的命令位置与测量位置之间的差异。使用基准模体和两个临床病例中的 Gafchromic EBT3 胶片进行剂量学验证。

结果

位置精度的均方根误差(RMSE)在 0.31mm 以内。机械精度的 RMSE 对于旋转机架为 0.14°,对于 MLC 为 0.11±0.02mm,对于万向节位置为 0.13mm。基准模体和两个临床病例的 3%/3mm 伽马指数通过率均大于 83.3%和 91.2%。

结论

评估了 DTT-VMAT 的位置、机械和剂量学准确性。使用万向节安装直线加速器的 DTT-VMAT 具有足够的准确性,为治疗具有呼吸运动的多种肿瘤提供了一种新策略。

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