Fairleigh Dickinson University, School of Pharmacy, Florham Park, NJ, USA.
The Cancer Epidemiology Division, Cancer Center and Institute of Oncology, Warsaw, Poland.
Eur J Intern Med. 2018 Apr;50:47-51. doi: 10.1016/j.ejim.2017.11.005. Epub 2017 Nov 12.
Hypercholesterolemia treatment guidelines emphasize an adequate whole grains (WG) intake, alone or complementary to pharmacological treatment. We conducted this study to compare the prevalence of adequate WG intake and levels of blood lipids according to the statin/WG intake status.
This cross-sectional analysis of a community-based study included 12,754 men and women, age 45-64. Statin use over past 30days was recorded by trained nurses. Food intake over past 12months was assessed by a validated food-frequency questionnaire. Adequate WG intake was defined as ≥3oz-equivalents/day, representing ≥3WGservings/day.
The prevalence of an adequate WG intake was marginally superior in statin users (26.79%) than non-users (21.51%). This superiority was attenuated after multiple covariates adjustment (PR 1.12, 95%CI 1.02-1.22). Statin users with an adequate WG intake had lower multivariable-adjusted mean blood total cholesterol (185.14mg/dL vs. 190.14mg/dL) and LDL cholesterol (103.30mg/dL vs. 108.19mg/dL) than those with an inadequate WG intake. Statin users with an adequate WG intake had lower odds (OR, 95% CI) of having TC≥240mg/dL (OR 0.67, 95% CI 0.46-0.98) and lower odds of having LDL≥100mg/dL (OR 0.72, 95% CI 0.58-0.89), compared to statin users with inadequate WG intake. A subgroup analysis restricted to those with prevalent CVD yielded similar results.
In this community based sample of middle-aged adults, only one in four statin users had adequate whole grain intake. Statin users with adequate WG intake had statistically and clinically significant lower levels of blood total- and LDL-cholesterol.
高胆固醇血症治疗指南强调，应充分摄入全谷物（WG），单独或与药物治疗相结合。我们进行这项研究是为了比较根据他汀类药物/WG 摄入量状况，充分摄入 WG 的比例和血脂水平。
这是一项基于社区的研究的横断面分析，共纳入 12754 名 45-64 岁的男性和女性。由经过培训的护士记录过去 30 天内他汀类药物的使用情况。通过经过验证的食物频率问卷评估过去 12 个月的食物摄入量。充分摄入 WG 的定义为≥3oz 当量/天，即每天≥3 份 WG。
与非使用者（21.51%）相比，他汀类药物使用者（26.79%）充分摄入 WG 的比例略高。这种优势在调整了多个协变量后减弱（PR 1.12，95%CI 1.02-1.22）。充分摄入 WG 的他汀类药物使用者的多变量调整后平均血总胆固醇（185.14mg/dL 与 190.14mg/dL）和 LDL 胆固醇（103.30mg/dL 与 108.19mg/dL）均低于摄入不足的患者。与摄入不足的患者相比，充分摄入 WG 的他汀类药物使用者具有更低的 TC≥240mg/dL 的可能性（OR，95%CI）（OR 0.67，95%CI 0.46-0.98）和 LDL≥100mg/dL 的可能性（OR 0.72，95%CI 0.58-0.89）。在仅限于有 CVD 既往史的亚组分析中，也得到了相似的结果。
在这个以社区为基础的中年成年人样本中，只有四分之一的他汀类药物使用者充分摄入 WG。充分摄入 WG 的他汀类药物使用者的血总胆固醇和 LDL 胆固醇水平具有统计学意义和临床意义上的降低。
