Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan; Comprehensive Cancer Center, University of Michigan, Ann Arbor, Michigan.
Department of Pathology, International Center for the Study of Breast Cancer Subtypes, Henry Ford Health System and Henry Ford Cancer Institute, Detroit, Michigan.
Am J Pathol. 2018 Feb;188(2):271-279. doi: 10.1016/j.ajpath.2017.06.020. Epub 2017 Nov 11.
Triple-negative breast cancers (TNBCs) are more common among African-ancestry populations, such as African Americans and western, sub-Saharan Africans, compared with European-ancestry populations. This phenotype prevalence contributes to disparities in breast cancer outcomes between African Americans and White Americans. Breast cancer stem cells represent the tumor subpopulation involved in metastatic virulence, and ongoing research seeks to characterize the extent to which TNBC versus non-TNBC stem cells may differ. This review summarizes the existing literature regarding TNBCs and stem cells as they pertain to the burden of breast cancer among African-ancestry populations. Additional research related to variations in somatic tumor genomics between the African-American and White-American populations is also summarized. This review furthermore explores the history of insights regarding breast cancer disparities related to racial/ethnic identity, socioeconomic status, and tumor biology.
三阴性乳腺癌（TNBC）在非洲裔人群中更为常见，例如非裔美国人和西部撒哈拉以南非洲人，而在欧洲裔人群中则较少见。这种表型的流行导致了非裔美国人和白种人之间乳腺癌结局的差异。乳腺癌干细胞代表了参与转移毒性的肿瘤亚群，目前的研究旨在描述 TNBC 与非 TNBC 干细胞之间可能存在的差异程度。本综述总结了关于 TNBC 和干细胞的现有文献，这些文献与非洲裔人群中的乳腺癌负担有关。还总结了与非裔美国人和白种人之间体细胞肿瘤基因组学差异相关的其他研究。本综述还探讨了与种族/民族身份、社会经济地位和肿瘤生物学相关的乳腺癌差异的见解的历史。
