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乳腺癌与非洲裔血统的差异:全球视角

Disparities in breast cancer and african ancestry: a global perspective.

作者信息

Newman Lisa A

机构信息

Department of Surgery, Breast Care Center, University of Michigan Comprehensive Cancer Center, Ann Arbor, Michigan.

出版信息

Breast J. 2015 Mar-Apr;21(2):133-9. doi: 10.1111/tbj.12369. Epub 2015 Jan 9.

Abstract

Recognition of breast cancer disparities between African-American and White American women has generated exciting research opportunities investigating the biologic and hereditary factors that contribute to the observed outcome differences, leading to international studies of breast cancer in Africa. The study of breast cancer in women with African ancestry has opened the door to unique investigations regarding breast cancer subtypes and the genetics of this disease. International research efforts can advance our understanding of race/ethnicity-associated breast cancer disparities within the USA; the pathogenesis of triple negative breast cancer; and hereditary susceptibility for breast cancer.

摘要

认识到非裔美国女性和美国白人女性在乳腺癌方面的差异,催生了令人兴奋的研究机会,即调查导致观察到的结果差异的生物学和遗传因素,进而促成了在非洲开展的乳腺癌国际研究。对有非洲血统女性的乳腺癌研究为有关乳腺癌亚型和该疾病遗传学的独特调查打开了大门。国际研究工作能够增进我们对美国境内与种族/族裔相关的乳腺癌差异、三阴性乳腺癌的发病机制以及乳腺癌遗传易感性的理解。

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