Kirschbaum B B, Schoolwerth A C
Department of Medicine, Medical College of Virginia, Richmond 23298-0160.
Am J Med Sci. 1989 Jan;297(1):9-11. doi: 10.1097/00000441-198901000-00003.
The authors report the development of a rapidly progressive encephalopathy marked by confusion, myoclonus, seizures, coma, and death in a group of women with renal failure who received an oral solution of citrate and aluminum hydroxide gel concurrently. Two patients were documented as having marked hyperaluminemia far exceeding blood aluminum levels encountered in the chronic state of aluminum intoxication. We ascribe the toxicity to enhanced gastrointestinal absorption of aluminum when complexed with citrate.
作者报告了一组肾衰竭女性患者出现的一种快速进展性脑病，其特征为意识模糊、肌阵挛、癫痫发作、昏迷和死亡，这些患者同时接受了枸橼酸盐口服溶液和氢氧化铝凝胶。有两名患者被记录为存在明显的高铝血症，远远超过铝中毒慢性状态下所遇到的血铝水平。我们将这种毒性归因于铝与枸橼酸盐络合时胃肠道对铝的吸收增强。
