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中医临床试验的特点：对ClinicalTrials.gov的系统评价

The Characteristics of TCM Clinical Trials: A Systematic Review of ClinicalTrials.gov.

作者信息

Chen Junchao, Huang Jihan, Li Jordan V, Lv Yinghua, He Yingchun, Zheng Qingshan

机构信息

Center for Drug Clinical Research, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.

Medical Science & Computing, LLC, Rockville, MD 20852, USA.

出版信息

Evid Based Complement Alternat Med. 2017;2017:9461415. doi: 10.1155/2017/9461415. Epub 2017 Aug 24.

DOI:10.1155/2017/9461415
PMID:29138646
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5613643/
Abstract

OBJECTIVE

The aim of this review is to characterize current status of global TCM clinical trials registered in ClinicalTrials.gov.

METHODS

We examined all the trials registered within ClinicalTrials.gov up to 25 September 2015, focusing on study interventions to identify TCM-related trials, and extracted 1,270 TCM trials from the data set.

RESULTS

Overall, 691 (54.4%) trials were acupuncture, and 454 (35.8%) trials were herbal medicines. Differences in TCM trial intervention types were also evident among the specific therapeutic areas. Among all trials, 55.7% that were small studies enrolled <100 subjects, and only 8.7% of completed studies had reported results of trials. As for the location, the United States was second to China in conducting the most TCM trials.

CONCLUSION

This review is the first snapshot of the landscape of TCM clinical trials registered in ClinicalTrials.gov, providing the basis for treatment and prevention of diseases within TCM and offering useful information that will guide future research on TCM.

摘要

目的

本综述旨在描述在ClinicalTrials.gov上注册的全球中医药临床试验的现状。

方法

我们审查了截至2015年9月25日在ClinicalTrials.gov上注册的所有试验，重点关注研究干预措施以识别与中医药相关的试验，并从数据集中提取了1270项中医药试验。

结果

总体而言，691项（54.4%）试验为针灸试验，454项（35.8%）试验为草药试验。中医药试验干预类型在特定治疗领域之间也存在明显差异。在所有试验中，55.7%的小型研究纳入的受试者少于100名，只有8.7%的完成研究报告了试验结果。至于地点，美国在开展中医药试验方面仅次于中国。

结论

本综述是在ClinicalTrials.gov上注册的中医药临床试验情况的首次概述，为中医药疾病的治疗和预防提供了依据，并提供了将指导未来中医药研究的有用信息。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1a3e/5613643/ee4963d9bfa7/ECAM2017-9461415.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1a3e/5613643/d059147ff6eb/ECAM2017-9461415.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1a3e/5613643/1da36a26d52d/ECAM2017-9461415.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1a3e/5613643/095df7c664c3/ECAM2017-9461415.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1a3e/5613643/d183569d2ef9/ECAM2017-9461415.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1a3e/5613643/ee4963d9bfa7/ECAM2017-9461415.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1a3e/5613643/d059147ff6eb/ECAM2017-9461415.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1a3e/5613643/1da36a26d52d/ECAM2017-9461415.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1a3e/5613643/095df7c664c3/ECAM2017-9461415.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1a3e/5613643/d183569d2ef9/ECAM2017-9461415.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1a3e/5613643/ee4963d9bfa7/ECAM2017-9461415.005.jpg

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