Southern Medical University, Guangzhou, Guangdong 510515, P.R. China.
Department of General Surgery, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou, Guangdong 510080, P.R. China.
Mol Med Rep. 2018 Jan;17(1):1986-1992. doi: 10.3892/mmr.2017.8047. Epub 2017 Nov 14.
Friend leukemia virus integration 1 (Fli‑1) is a newly identified ETS protein, and has critical roles in many malignancies. However, the physiological characters and potential mechanisms of Fli‑1 in hepatocellular carcinoma (HCC) progression remains unclear. In the present study, Fli‑1 was highly expressed in HCC samples and tumor cell lines. knockdown of Fli‑1 with small interfering (si)RNAs significantly reduced the colony formation and metastasis capacity of HCC cell lines in vitro. Subsequent investigation identified that Fli‑1 functioned as an oncogene in HCC carcinogenesis and it exerted its promoting metastatic effect primarily by modulating the matrix metalloproteinase (MMP)2 signaling pathway. Collectively, these data provide a novel insight into the mechanism of Fli‑1/MMP2 signaling pathway in the pathogenesis of HCC, and Fli‑1 may serve as a novel therapeutic target for HCC.
Friend 白血病病毒整合 1（Fli-1）是一种新发现的 ETS 蛋白，在许多恶性肿瘤中具有关键作用。然而，Fli-1 在肝细胞癌（HCC）进展中的生理特征和潜在机制尚不清楚。在本研究中，Fli-1 在 HCC 样本和肿瘤细胞系中高表达。用小干扰（si）RNA 敲低 Fli-1 显著降低了 HCC 细胞系在体外的集落形成和转移能力。随后的研究表明，Fli-1 在 HCC 发生中作为一种癌基因发挥作用，它主要通过调节基质金属蛋白酶（MMP）2 信号通路发挥促进转移的作用。总之，这些数据为 Fli-1/MMP2 信号通路在 HCC 发病机制中的作用提供了新的见解，Fli-1 可能成为 HCC 的一个新的治疗靶点。
