Department of Translational Medical Sciences, Allergy and Clinical Immunology. Center for Basic and Clinical Immunology Research (CISI), University of Naples Federico II, Via S. Pansini 5, 80131, Naples, Italy.
Department of Advanced Biomedical Sciences, University of Naples Federico II, Via S. Pansini 5, 80131, Naples, Italy.
J Clin Immunol. 2018 Jan;38(1):67-76. doi: 10.1007/s10875-017-0461-z. Epub 2017 Nov 14.
Common variable immunodeficiency (CVID) is a primary immunodeficiency characterized by reduced immunoglobulin serum levels and absent or impaired antibody production. Clinical manifestations, including infections, inflammatory and autoimmune diseases, and malignancies, also involve various segments of the gastrointestinal tract. Chronic diarrhea is one of the most common gastrointestinal symptoms and may cause a wide spectrum of potentially life-threatening conditions as malabsorption and protein-energy malnutrition. We describe three female CVID adult patients presenting with chronic diarrhea, weight loss, and protein-energy malnutrition due to different underlying conditions. Our review of the literature explores the various gastrointestinal involvements in CVID and points out several histopathological findings proper of the disease, thus highlighting the relevance of the endoscopic and histological assessment in CVID patients presenting with chronic diarrhea.
普通变异性免疫缺陷病（CVID）是一种以血清免疫球蛋白水平降低和抗体产生缺失或受损为特征的原发性免疫缺陷病。临床表现包括感染、炎症和自身免疫性疾病以及恶性肿瘤，也涉及胃肠道的各个部位。慢性腹泻是最常见的胃肠道症状之一，可因吸收不良和蛋白质能量营养不良而导致广泛的潜在危及生命的病症。我们描述了 3 例因不同潜在疾病而出现慢性腹泻、体重减轻和蛋白质能量营养不良的 CVID 成年女性患者。我们对文献的回顾探讨了 CVID 中各种胃肠道受累情况，并指出了疾病特有的几种组织病理学发现，从而强调了在出现慢性腹泻的 CVID 患者中进行内镜和组织学评估的相关性。
