Bai Taoping, Jiang Wentao, Fan Yubo
Department of Applied Mechanics, Sichuan University, Chengdu, China.
Bioengineering Department, School of Biological Science and Medical Engineering, Beihang University, Beijing, China.
Dermatol Surg. 2018 May;44(5):689-696. doi: 10.1097/DSS.0000000000001402.
Despite the popularity of sclerotherapy for treating varicose veins, it still exhibits various problems, such as pulmonary embolism, deep-vein thrombosis, phlebitis, and visual disorders.
To investigate syringe volume influence on foam stability, obtain the foam decay rule, and provide a reference for clinics.
Five types of syringes are used to prepare foam at room temperature with various liquid-gas ratios. Foam decay process experiments were performed 5 times and recorded by video. The stability indices used include drainage time, half-life, bubble diameter, bubble surface density, and drainage rate.
The 30 and 2-mL syringes, respectively, recorded the highest and lowest drainage speeds. Foam drainage time and half-life, differences varied between 15 and 70 seconds, and 20 and 100 seconds, respectively. Foam bubble diameters were distributed over 0.1 to 2.0 mm with roughly 200 to 700 bubbles per square centimeter.
Increased syringe volume causes the bubble diameter to increase. Thus, foam dispersion increases and foam half-life decreases; hence, foam becomes unstable. It is, thus, better to use a small syringe several times to prepare foam in clinics using segmented injections.
尽管硬化疗法在治疗静脉曲张方面很受欢迎，但它仍然存在各种问题，如肺栓塞、深静脉血栓形成、静脉炎和视力障碍。
研究注射器容积对泡沫稳定性的影响，得出泡沫衰减规律，为临床提供参考。
使用五种类型的注射器在室温下以不同的液气比制备泡沫。泡沫衰减过程实验进行5次，并通过视频记录。所使用的稳定性指标包括排水时间、半衰期、气泡直径、气泡表面密度和排水速率。
30 mL和2 mL注射器分别记录了最高和最低的排水速度。泡沫排水时间和半衰期差异分别在15至70秒和20至100秒之间。泡沫气泡直径分布在0.1至2.0毫米之间，每平方厘米约有200至700个气泡。
注射器容积增加会导致气泡直径增大。因此，泡沫分散度增加且泡沫半衰期缩短；因此，泡沫变得不稳定。因此，在临床中采用分段注射时，最好多次使用小注射器来制备泡沫。
