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Hepatic peroxisome proliferator-activated receptor alpha mediates the major metabolic effects of Wy-14643.
J Gastroenterol Hepatol. 2018 May;33(5):1138-1145. doi: 10.1111/jgh.14046. Epub 2018 Feb 19.
2
Hepatocyte peroxisome proliferator-activated receptor α regulates bile acid synthesis and transport.
Biochim Biophys Acta Mol Cell Biol Lipids. 2019 Oct;1864(10):1396-1411. doi: 10.1016/j.bbalip.2019.05.014. Epub 2019 Jun 10.
4
Plasma mannose-binding lectin is stimulated by PPARα in humans.
Am J Physiol Endocrinol Metab. 2012 Mar 1;302(5):E595-602. doi: 10.1152/ajpendo.00299.2011. Epub 2012 Jan 3.
5
PPARalpha activation increases triglyceride mass and adipose differentiation-related protein in hepatocytes.
J Lipid Res. 2006 Feb;47(2):329-40. doi: 10.1194/jlr.M500203-JLR200. Epub 2005 Nov 10.
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Hepatic sirtuin 1 is dispensable for fibrate-induced peroxisome proliferator-activated receptor-α function in vivo.
Am J Physiol Endocrinol Metab. 2014 Apr 1;306(7):E824-37. doi: 10.1152/ajpendo.00175.2013. Epub 2014 Feb 4.
10
Hepatocyte-specific PPARA expression exclusively promotes agonist-induced cell proliferation without influence from nonparenchymal cells.
Am J Physiol Gastrointest Liver Physiol. 2017 Mar 1;312(3):G283-G299. doi: 10.1152/ajpgi.00205.2016. Epub 2017 Jan 12.

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Neutrophils secrete exosome-associated DNA to resolve sterile acute inflammation.
Nat Cell Biol. 2025 May 22. doi: 10.1038/s41556-025-01671-4.
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Gene repression through epigenetic modulation by PPARA enhances hepatocellular proliferation.
iScience. 2022 Apr 4;25(5):104196. doi: 10.1016/j.isci.2022.104196. eCollection 2022 May 20.
9
Circadian Regulation of Gene Expression and Metabolism in the Liver.
Semin Liver Dis. 2022 May;42(2):113-121. doi: 10.1055/a-1792-4240. Epub 2022 Mar 9.
10
PPARα agonist WY-14,643 enhances ethanol metabolism in mice: Role of catalase.
Free Radic Biol Med. 2021 Jun;169:283-293. doi: 10.1016/j.freeradbiomed.2021.04.018. Epub 2021 Apr 20.

本文引用的文献

1
Hepatocyte-specific PPARA expression exclusively promotes agonist-induced cell proliferation without influence from nonparenchymal cells.
Am J Physiol Gastrointest Liver Physiol. 2017 Mar 1;312(3):G283-G299. doi: 10.1152/ajpgi.00205.2016. Epub 2017 Jan 12.
2
Liver PPARα is crucial for whole-body fatty acid homeostasis and is protective against NAFLD.
Gut. 2016 Jul;65(7):1202-14. doi: 10.1136/gutjnl-2015-310798. Epub 2016 Feb 1.
4
HMG-CoA Reductase Inhibitors Bind to PPARα to Upregulate Neurotrophin Expression in the Brain and Improve Memory in Mice.
Cell Metab. 2015 Aug 4;22(2):253-65. doi: 10.1016/j.cmet.2015.05.022. Epub 2015 Jun 25.
5
Activation of peroxisome proliferator-activated receptor α stimulates ADAM10-mediated proteolysis of APP.
Proc Natl Acad Sci U S A. 2015 Jul 7;112(27):8445-50. doi: 10.1073/pnas.1504890112. Epub 2015 Jun 15.
6
Integration of body temperature into the analysis of energy expenditure in the mouse.
Mol Metab. 2015 Mar 10;4(6):461-70. doi: 10.1016/j.molmet.2015.03.001. eCollection 2015 Jun.
8
Integrated physiology and systems biology of PPARα.
Mol Metab. 2014 Mar 6;3(4):354-71. doi: 10.1016/j.molmet.2014.02.002. eCollection 2014 Jul.
9
Energy metabolism in the liver.
Compr Physiol. 2014 Jan;4(1):177-97. doi: 10.1002/cphy.c130024.

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