Bogush T A, Sitdikova S M, Lokshin A
Biull Eksp Biol Med. 1989 Jan;107(1):43-5.
Cu-2, a new Soviet copper-complexed cytostatic, decreased acute and hematologic toxicity after lethal doses of adriamycin (AD) were given to male CBA mice. Cu-2 (3.5 mg/kg) was first injected 10 minutes after AD was given, and a second injection followed 50 minutes after the first. Relative to controls given AD alone, the mortality of Cu-2 treated mice was decreased and their lifespan increased. Leukopenia also was less pronounced and of shorter duration. The observed effect of Cu-2 may be related to its superoxide dismutase activity, which may inactivate free radical by-products of AD metabolism known to contribute significantly to the toxicity of this anti-cancer antibiotic.
Cu - 2是一种新型的苏联铜络合细胞抑制剂，在给雄性CBA小鼠注射致死剂量的阿霉素（AD）后，它能降低急性毒性和血液学毒性。在给予AD后10分钟首次注射Cu - 2（3.5毫克/千克），并在首次注射后50分钟进行第二次注射。与单独给予AD的对照组相比，接受Cu - 2治疗的小鼠死亡率降低，寿命延长。白细胞减少也不那么明显，持续时间更短。观察到的Cu - 2的作用可能与其超氧化物歧化酶活性有关，超氧化物歧化酶活性可能使AD代谢产生的自由基副产物失活，已知这些自由基副产物对这种抗癌抗生素的毒性有显著影响。
