[Early post-toxic defects in hepatocyte membranes revealed by electron microscopy with the aid of a lanthanum transmembrane tracer].

At early stages of CCl4 treatment defects of hepatocyte membranes are formed as a result of free radical oxidation lipids and Ca2+ accumulation by cells from extracellular media. The formation of membrane's pores precedes the development of ultrastructural changes of hepatocytes during CCl4 treatment and this is the result of membrane damage.